Naturalistic Intensities of Light at Night: A Review of the Potent Effects of Very Dim Light on Circadian Responses and Considerations for Translational Research.

Naturalistic Intensities of Light at Night: A Review of the Potent Effects of Very Dim Light on Circadian Responses and Considerations for Translational Research.
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DOI:
10.3389/fneur.2021.625334
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发表时间:
2021
影响因子:
3.4
通讯作者:
Glickman GL
Glickman GL
中科院分区:
医学3区
文献类型:
--
作者:
Walbeek TJ;Harrison EM;Gorman MR;Glickman GL

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在这篇综述中,我们讨论了一种在昼夜节律背景下经常被忽视的光的显着效力和潜在应用:夜间昏暗光的自然水平(nLAN),相当于月亮和星星产生的强度。人们通常认为,如此低的光水平不会产生通常与较亮的光水平相关的昼夜节律反应。由于广泛使用了有些含糊的术语“暗光”,对极低光照水平的影响的深入理解变得更加复杂,该术语已被用来描述七个数量级的光照水平。在这里,我们提出了这样的论点:nLAN 对许多哺乳动物物种具有强大的昼夜节律影响,并且考虑到解剖结构和功能的保护,该范围内的光对人类的功效值得进一步研究。我们还为时间生物学研究领域提供建议,包括光测量和报告的最低要求、术语标准化(特别是与“暗淡”光有关)以及重新考虑旧数据和设计新研究的想法。
In this review, we discuss the remarkable potency and potential applications of a form of light that is often overlooked in a circadian context: naturalistic levels of dim light at night (nLAN), equivalent to intensities produced by the moon and stars. It is often assumed that such low levels of light do not produce circadian responses typically associated with brighter light levels. A solid understanding of the impacts of very low light levels is complicated further by the broad use of the somewhat ambiguous term “dim light,” which has been used to describe light levels ranging seven orders of magnitude. Here, we lay out the argument that nLAN exerts potent circadian effects on numerous mammalian species, and that given conservation of anatomy and function, the efficacy of light in this range in humans warrants further investigation. We also provide recommendations for the field of chronobiological research, including minimum requirements for the measurement and reporting of light, standardization of terminology (specifically as it pertains to “dim” light), and ideas for reconsidering old data and designing new studies.
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