Distribution and overlap of entorhinal, premotor, and amygdalar connections in the monkey anterior cingulate cortex.
Distribution and overlap of entorhinal, premotor, and amygdalar connections in the monkey anterior cingulate cortex.
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猴子前扣带皮层内嗅、前运动和杏仁核联系的分布和重叠。
DOI：
10.1002/cne.24986
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Medalla M
中科院分区：
文献类型：
--
作者：
Calderazzo SM;Busch SE;Moore TL;Rosene DL;Medalla M
前扣带皮层（ACC）对决策非常重要，因为它将运动计划与情感和背景边缘信息整合在一起。在抑郁症、双相情感障碍和创伤后应激障碍中观察到这些网络的中断。然而，重叠的边缘和运动连接内的ACC的细分还没有得到很好的理解。因此，我们管理的组合逆行和顺行示踪剂进入结构的重要上下文记忆（内嗅皮层），情感处理（杏仁核），和运动规划（背侧运动前皮层），以评估标记的投射神经元（输出）和轴突终端（输入）的成年恒河猴（猕猴）的ACC的重叠。我们的数据表明，内嗅和背侧运动前皮层（dPMC）连接分离腹侧（A25，A24a）和背侧（A24b，c）的ACC的子区域，而杏仁核连接更均匀地分布在各子区域。在所有区域中，吻侧ACC（A32）与所有三个区域的连接相对密度最低。在腹侧ACC，内嗅和杏仁核连接强烈重叠在所有层，特别是在A25。在背侧ACC，输出到dPMC和杏仁核强烈重叠在深层。然而，背侧ACC的dPMC的输入是denerably在深层，而杏仁核的输入主要集中在上层。这些连接模式与背侧ACC在运动评价中的不同作用以及腹侧ACC在情感和背景记忆中的不同作用是一致的。此外，不同的层状电路表明特定的前扣带回隔间内的独特的相互作用，这可能是重要的运动和边缘系统的信息在灵活的目标导向行为的时间整合。
The anterior cingulate cortex (ACC) is important for decision-making as it integrates motor plans with affective and contextual limbic information. Disruptions in these networks have been observed in depression, bipolar disorder, and post-traumatic stress disorder. Yet, overlap of limbic and motor connections within subdivisions of the ACC is not well understood. Hence, we administered a combination of retrograde and anterograde tracers into structures important for contextual memories (entorhinal cortex), affective processing (amygdala), and motor planning (dorsal premotor cortex) to assess overlap of labeled projection neurons from (outputs) and axon terminals to (inputs) the ACC of adult rhesus monkeys (Macaca mulatta). Our data show that entorhinal and dorsal premotor cortical (dPMC) connections are segregated across ventral (A25, A24a) and dorsal (A24b,c) subregions of the ACC, while amygdalar connections are more evenly distributed across subregions. Among all areas, the rostral ACC (A32) had the lowest relative density of connections with all three regions. In the ventral ACC, entorhinal and amygdalar connections strongly overlap across all layers, especially in A25. In the dorsal ACC, outputs to dPMC and the amygdala strongly overlap in deep layers. However, dPMC input to the dorsal ACC was densest in deep layers, while amygdalar inputs predominantly localized in upper layers. These connection patterns are consistent with diverse roles of the dorsal ACC in motor evaluation and the ventral ACC in affective and contextual memory. Further, distinct laminar circuits suggest unique interactions within specific ACC compartments that are likely important for the temporal integration of motor and limbic information during flexible goal-directed behavior.
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DOI：
10.1523/jneurosci.2581-12.2012
发表时间：
2012-10-03
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Amatrudo JM;Weaver CM;Crimins JL;Hof PR;Rosene DL;Luebke JI
通讯作者：
Luebke JI
影响因子：
3.1
作者：
Canto CB;Wouterlood FG;Witter MP
通讯作者：
Witter MP
影响因子：
3.5
作者：
Barbas, H;Blatt, GJ
通讯作者：
Blatt, GJ
影响因子：
2.4
作者：
Barbas H;Saha S;Rempel-Clower N;Ghashghaei T
通讯作者：
Ghashghaei T
影响因子：
2.7
作者：
Anderson MC;Bunce JG;Barbas H
通讯作者：
Barbas H