Advancing Yarrowia lipolytica as a superior biomanufacturing platform by tuning gene expression using promoter engineering.
Advancing Yarrowia lipolytica as a superior biomanufacturing platform by tuning gene expression using promoter engineering.
复制标题
通过使用启动子工程调节基因表达，将解脂耶氏酵母推进为卓越的生物制造平台。
DOI：
10.1016/j.biortech.2022.126717
复制
发表时间：
2022-01
影响因子：
11.4
通讯作者：
Ji Xiao-Jun
中科院分区：
文献类型：
--
作者：
Sun Mei-Li;Shi Tian-Qiong;Lin Lu;Ledesma-Amaro Rodrigo;Ji Xiao-Jun
Yarrowia lipolyticais recognized as an excellent non-conventional yeast in the field of biomanufacturing, where it is used as a host to produce oleochemicals, terpenes, organic acids, polyols and recombinant proteins. Consequently, metabolic engineering of this yeast is becoming increasingly popular to advance it as a superior biomanufacturing platform, of which promoters are the most basic elements for tuning gene expression. Endogenous promoters ofYarrowia lipolyticawere reviewed, which are the basis for promoter engineering. The engineering strategies, such as hybrid promoter engineering, intron enhancement promoter engineering, and transcription factor-based inducible promoter engineering are described. Additionally, the applications ofYarrowia lipolyticapromoter engineering to rationally reconstruct biosynthetic gene clusters and improve the genome-editing efficiency of the CRISPR-Cas systems were reviewed. Finally, research needs and future directions for promoter engineering are also discussed in this review.
登录
查看更多内容
DOI：
10.3390/jof7070548
发表时间：
2021-07-10
期刊：
Journal of fungi (Basel, Switzerland)
影响因子：
--
作者：
Madzak C
通讯作者：
Madzak C
影响因子：
11.4
作者：
Wenyan Tang;Dong-Ping Wang;Yun Tian;Xiao Fan;Chong Wang;Xiangyang Lu;Peiwang Li;Xiaojun Ji;Huhu Liu
通讯作者：
Wenyan Tang;Dong-Ping Wang;Yun Tian;Xiao Fan;Chong Wang;Xiangyang Lu;Peiwang Li;Xiaojun Ji;Huhu Liu
DOI：
--
发表时间：
1988
期刊：
--
影响因子：
--
作者：
A. Franke;F. Kaczmarek;M. Eisenhard;K. Geoghegan;D. Danley;J. D. Zeeuw;M. M. O'donnell-M.;M. G. Gollaher;L. Davidow
通讯作者：
A. Franke;F. Kaczmarek;M. Eisenhard;K. Geoghegan;D. Danley;J. D. Zeeuw;M. M. O'donnell-M.;M. G. Gollaher;L. Davidow
工程解脂耶氏酵母利用木糖生产燃料和化学品：综述
影响因子：
11.4
作者：
Sun Tao;Yu Yizi;Wang Kaifeng;Ledesma-Amaro Rodrigo;Ji Xiao-Jun
通讯作者：
Ji Xiao-Jun
影响因子：
6.4
作者：
Sassi H;Delvigne F;Kar T;Nicaud JM;Coq AM;Steels S;Fickers P
通讯作者：
Fickers P