Primary Disruption of the Memory-Related Subsystems of the Default Mode Network in Alzheimer's Disease: Resting-State Functional Connectivity MRI Study.
Primary Disruption of the Memory-Related Subsystems of the Default Mode Network in Alzheimer's Disease: Resting-State Functional Connectivity MRI Study.
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DOI：
10.3389/fnagi.2018.00344
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发表时间：
2018
影响因子：
4.8
通讯作者：
Zhao X
中科院分区：
文献类型：
--
作者：
Qi H;Liu H;Hu H;He H;Zhao X
背景：最近的研究表明，默认模式网络（DMN）至少包括三个子系统：内侧颞叶（MTL）和背内侧前额叶皮层（DMPFC）子系统，以及由前内侧前额叶皮层（aMPFC）和后扣带皮层（PCC）组成的核心。此外，DMN的破坏与阿尔茨海默病（AD）有关。然而，对于阿尔茨海默病中这些子系统的变化知之甚少，阿尔茨海默病是一种以记忆障碍为特征的进行性疾病。在这里，我们进行了静息状态功能连接（FC）分析，以验证我们的假设，即记忆相关的MTL子系统在AD中主要被破坏。方法：为了揭示具体的子系统变化，我们计算了个体DMN内和子系统间FCS的强度和数量，并比较了两组的FC。为了进一步研究哪对脑区域功能连接导致了子系统的改变，我们比较了DMN中任意两个脑区域之间的相关系数。此外，为了确定哪些区域对子系统变化的贡献最大，我们计算了区域FC强度（FCS），并在组间进行了比较。结果：在子系统内，AD患者MTL子系统中出现FC数量和强度下降，而DMPFC子系统或核心中未出现FC数量和强度下降。在子系统间，AD组MTL子系统与PCC之间的FCS和数量减少，PCC与DMPFC子系统之间的FCS和数量减少。与对照组相比，AD患者MTL子系统的区域间FCS减少：后下顶叶（pIPL）的FC随着海马形成（HF）、海马旁皮层（PHC）和腹侧MPFC （vMPFC）的减少而减少。在AD患者中也发现了子系统间区域间FCS的减少：HF和/或PHC的dMPFC和TPJ（位于dMPFC子系统）以及PCC的FC减少。AD患者在dMPFC子系统的PCC和TLC之间的FC也减少。此外，MTL子系统的HF和PHC显示区域FCS降低。结论：AD组内禀FC降低主要与MTL子系统有关，提示MTL子系统主要被破坏。
Background: Recent studies have indicated that the default mode network (DMN) comprises at least three subsystems: The medial temporal lobe (MTL) and dorsal medial prefrontal cortex (DMPFC) subsystems and a core comprising the anterior MPFC (aMPFC) and posterior cingulate cortex (PCC). Additionally, the disruption of the DMN is related to Alzheimer’s disease (AD). However, little is known regarding the changes in these subsystems in AD, a progressive disease characterized by memory impairment. Here, we performed a resting-state functional connectivity (FC) analysis to test our hypothesis that the memory-related MTL subsystem was predominantly disrupted in AD. Method: To reveal specific subsystem changes, we calculated the strength and number of FCS in the DMN intra- and inter-subsystems across individuals and compared the FC of the two groups. To further examine which pairs of brain regional functional connections contributed to the subsystem alterations, correlation coefficients between any two brain regions in the DMN were compared across groups. Additionally, to identify which regions made the strongest contributions to the subsystem changes, we calculated the regional FC strength (FCS), which was compared across groups. Results: For the intra-subsystem, decreased FC number and strength occurred in the MTL subsystem of AD patients but not in the DMPFC subsystem or core. For the inter-subsystems, the AD group showed decreased FCS and number between the MTL subsystem and PCC and a decreased number between the PCC and DMPFC subsystem. Decreased inter-regional FCS were found within the MTL subsystem in AD patients relative to controls: The posterior inferior parietal lobule (pIPL) showed decreased FC with the hippocampal formation (HF), parahippocampal cortex (PHC) and ventral MPFC (vMPFC). Decreased inter-regional FCS of the inter-subsystems were also found in AD patients: The HF and/or PHC showed decreased FC with dMPFC and TPJ, located in the DMPFC subsystem, and with PCC. AD patients also showed decreased FC between the PCC and TLC of the dMPFC subsystem. Furthermore, the HF and PHC in the MTL subsystem showed decreased regional FCS. Conclusion: Decreased intrinsic FC was mainly associated with the MTL subsystem of the AD group, suggesting that the MTL subsystem is predominantly disrupted.
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DOI：
10.1177/1073858411403316
发表时间：
2012-06
期刊：
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
影响因子：
--
作者：
Andrews-Hanna JR
通讯作者：
Andrews-Hanna JR
DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
DOI：
10.1073/pnas.2235925100
发表时间：
2003-11-25
影响因子：
11.1
作者：
Lustig, C;Snyder, AZ;Buckner, RL
通讯作者：
Buckner, RL
影响因子：
5.7
作者：
Kim, Hongkeun
通讯作者：
Kim, Hongkeun
DOI：
10.1073/pnas.0308627101
发表时间：
2004-03-30
影响因子：
11.1
作者：
Greicius, MD;Srivastava, G;Menon, V
通讯作者：
Menon, V