Gut Microbiota: A Contributing Factor to Obesity.
Gut Microbiota: A Contributing Factor to Obesity.
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DOI：
10.3389/fcimb.2016.00095
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发表时间：
2016
影响因子：
5.7
通讯作者：
Azhar EI
中科院分区：
文献类型：
--
作者：
Harakeh SM;Khan I;Kumosani T;Barbour E;Almasaudi SB;Bahijri SM;Alfadul SM;Ajabnoor GM;Azhar EI
肥胖是现代的全球流行病，是心血管疾病（CVD）和糖尿病的危险因素。肥胖和超重在发达国家和发展中国家人口中的普遍性正在上升，给健康和经济资源带来巨大负担。因此，研究控制这一新出现的流行病至关重要。最近，宿主与其驻留的肠道微生物群（GM）的相互作用已被报道参与许多代谢疾病的发病机制，包括肥胖症、糖尿病和CVD。大约1014种微生物存在于人类下肠内，并且这1014种微生物中的许多已经与宿主发展了互惠或共生关系，并且积极参与宿主的许多生理过程。然而，生态失调（改变肠道微生物组成）与其他易感遗传和环境因素，可能有助于宿主代谢紊乱，导致许多疾病。因此，划定的作用，转基因作为一个促成因素肥胖是本审查的主要目标。由于营养基因组学、代谢组学、RNA沉默、表观遗传学和其他学科的重大进展，肥胖研究作为一个领域正在迅速扩大，这些学科可能导致新技术和方法的出现，以更好地解释微生物群和肥胖之间的因果关系。
Obesity, a global epidemic of the modern era, is a risk factor for cardiovascular diseases (CVD) and diabetes. The pervasiveness of obesity and overweight in both developed as well as developing populations is on the rise and placing a huge burden on health and economic resources. Consequently, research to control this emerging epidemic is of utmost importance. Recently, host interactions with their resident gut microbiota (GM) have been reported to be involved in the pathogenesis of many metabolic diseases, including obesity, diabetes, and CVD. Around 1014 microorganisms reside within the lower human intestine and many of these 1014 microorganisms have developed mutualistic or commensal associations with the host and actively involved in many physiological processes of the host. However, dysbiosis (altered gut microbial composition) with other predisposing genetic and environmental factors, may contribute to host metabolic disorders resulting in many ailments. Therefore, delineating the role of GM as a contributing factor to obesity is the main objective of this review. Obesity research, as a field is expanding rapidly due to major advances in nutrigenomics, metabolomics, RNA silencing, epigenetics, and other disciplines that may result in the emergence of new technologies and methods to better interpret causal relationships between microbiota and obesity.
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影响因子：
64.8
作者：
Chassaing B;Koren O;Goodrich JK;Poole AC;Srinivasan S;Ley RE;Gewirtz AT
通讯作者：
Gewirtz AT
影响因子：
5
作者：
Befus, Montina;Lowy, Franklin D.;Larson, Elaine L.
通讯作者：
Larson, Elaine L.
影响因子：
24.5
作者：
Dao, Maria Carlota;Everard, Amandine;Clement, Karine
通讯作者：
Clement, Karine
DOI：
10.1152/ajpgi.00024.2006
发表时间：
2007-02-01
影响因子：
4.5
作者：
Brun, Paola;Castagliuolo, Ignazio;Martines, Diego
通讯作者：
Martines, Diego
影响因子：
5.9
作者：
AlNuaim, AA;Bamgboye, EA;AlMazrou, Y
通讯作者：
AlMazrou, Y