Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts.
Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts.
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科学界的努力未能设计出有效的艾滋病疫苗，以致不得不考虑采用替代传统疫苗配方的方法。我们在此建议，HIV疫苗研究可以从非洲非人灵长类动物的天然猴免疫缺陷病毒（SIV）感染的研究中大大受益。SIV的自然宿主（例如，黑白眉猴、非洲绿猴和山魈）与人类感染艾滋病毒有许多相同的特征；然而，他们通常不会发展为免疫缺陷。这些自然的、非进行性SIV感染代表了一种进化适应，允许灵长类慢病毒与宿主免疫系统和平共存。这种适应不会导致病毒复制减少，而是涉及到CD4+ T细胞亚群的表型改变、有限的免疫激活和粘膜免疫的保留，所有这些都有助于避免疾病进展，并可能减少SIV的垂直传播。在这里，我们总结了目前对非洲非人灵长类动物SIV感染的理解，并讨论了如何揭示这些进化适应可能为新疫苗设计提供线索，这些疫苗设计可能会诱导有效的免疫反应，而不会产生过度免疫激活的有害后果。
The design of an effective AIDS vaccine has eluded the efforts of the scientific community to the point that alternative approaches to classic vaccine formulations have to be considered. We propose here that HIV vaccine research could greatly benefit from the study of natural simian immunodeficiency virus (SIV) infections of African nonhuman primates. Natural SIV hosts (for example, sooty mangabeys, African green monkeys and mandrills) share many features of HIV infection of humans; however, they usually do not develop immunodeficiency. These natural, nonprogressive SIV infections represent an evolutionary adaptation that allows a peaceful coexistence of primate lentiviruses and the host immune system. This adaptation does not result in reduced viral replication but, rather, involves phenotypic changes to CD4+ T cell subsets, limited immune activation and preserved mucosal immunity, all of which contribute to the avoidance of disease progression and, possibly, to the reduction of vertical SIV transmission. Here we summarize the current understanding of SIV infection of African nonhuman primates and discuss how unraveling these evolutionary adaptations may provide clues for new vaccine designs that might induce effective immune responses without the harmful consequences of excessive immune activation.
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影响因子：
64.8
作者：
Keele, Brandon F.;Jones, James Holland;Terio, Karen A.;Estes, Jacob D.;Rudicell, Rebecca S.;Wilson, Michael L.;Li, Yingying;Learn, Gerald H.;Beasley, T. Mark;Schumacher-Stankey, Joann;Wroblewski, Emily;Mosser, Anna;Raphael, Jane;Kamenya, Shadrack;Lonsdorf, Elizabeth V.;Travis, Dominic A.;Mlengeya, Titus;Kinsel, Michael J.;Else, James G.;Silvestri, Guido;Goodall, Jane;Sharp, Paul M.;Shaw, George M.;Pusey, Anne E.;Hahn, Beatrice H.
通讯作者：
Hahn, Beatrice H.
记忆中的CD4下调CD4+ T细胞体内使非洲绿色猴子具有对进行性Sivagm感染的抗性。
影响因子：
82.9
作者：
通讯作者：
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影响因子：
5.4
作者：
Broussard, SR;Staprans, SI;Allan, JS
通讯作者：
Allan, JS
影响因子：
4.4
作者：
Milush, Jeffrey M.;Reeves, Jacqueline D.;Sodora, Donald L.
通讯作者：
Sodora, Donald L.
影响因子：
5.4
作者：
Diop, OM;Gueye, P;Müller-Trutwin, MC
通讯作者：
Müller-Trutwin, MC