Interplay Between Peripheral and Central Inflammation in Autism Spectrum Disorders: Possible Nutritional and Therapeutic Strategies.
Interplay Between Peripheral and Central Inflammation in Autism Spectrum Disorders: Possible Nutritional and Therapeutic Strategies.
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DOI：
10.3389/fphys.2018.00184
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发表时间：
2018
影响因子：
4
通讯作者：
Mattace Raso G
中科院分区：
文献类型：
--
作者：
Cristiano C;Lama A;Lembo F;Mollica MP;Calignano A;Mattace Raso G
产前和产后因素会影响大脑发育和功能，影响健康结果，特别是与神经发育疾病有关，如自闭症谱系障碍（ASD）。母亲肥胖及其相关并发症与后代ASD风险增加有关。事实上，暴露于母体肥胖或高脂肪饮食的动物容易出现社交障碍和重复行为，这是自闭症的标志。在发育过程中，脂肪酸和糖，以及饱腹激素，如胰岛素和瘦素，以及与肥胖诱导的低度炎症相关的炎症因子，可能在神经内分泌系统和脑神经元回路调节后代行为的损害中发挥作用。另一方面，出生后因素，如分娩方式、压力、饮食或抗生素治疗与肠道微生物群组成的改变有关，扰乱了微生物群-肠道-脑轴。事实上，胃肠道和中枢神经系统之间的相互作用不仅通过神经，激素和免疫途径发生，而且还通过微生物衍生的代谢产物发生。不健康的围产期和出生后环境的改变，肠道微生物群的操纵，营养和饮食干预可能是通过靶向炎症过程和肠道微生物群预防或限制ASD的可能策略。
Pre- and post-natal factors can affect brain development and function, impacting health outcomes with particular relevance to neurodevelopmental diseases, such as autism spectrum disorders (ASDs). Maternal obesity and its associated complications have been related to the increased risk of ASDs in offspring. Indeed, animals exposed to maternal obesity or high fat diets are prone to social communication impairment and repetitive behavior, the hallmarks of autism. During development, fatty acids and sugars, as well as satiety hormones, like insulin and leptin, and inflammatory factors related to obesity-induced low grade inflammation, could play a role in the impairment of neuroendocrine system and brain neuronal circuits regulating behavior in offspring. On the other side, post-natal factors, such as mode of delivery, stress, diet, or antibiotic treatment are associated to a modification of gut microbiota composition, perturbing microbiota-gut-brain axis. Indeed, the interplay between the gastrointestinal tract and the central nervous system not only occurs through neural, hormonal, and immune pathways, but also through microbe-derived metabolic products. The modification of unhealthy perinatal and postnatal environment, manipulation of gut microbiota, nutritional, and dietary interventions could represent possible strategies in preventing or limiting ASDs, through targeting inflammatory process and gut microbiota.
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早期生活节目和神经发育障碍。
影响因子：
10.6
作者：
Bale, Tracy L.;Baram, Tallie Z.;Brown, Alan S.;Goldstein, Jill M.;Insel, Thomas R.;McCarthy, Margaret M.;Nemeroff, Charles B.;Reyes, Teresa M.;Simerly, Richard B.;Susser, Ezra S.;Nestler, Eric J.
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DOI：
10.1016/j.plefa.2006.02.001
发表时间：
2006-04-01
影响因子：
3
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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