Evolutionary History and Ongoing Transmission of Phylogenetic Sublineages of Mycobacterium tuberculosis Beijing Genotype in China.
Evolutionary History and Ongoing Transmission of Phylogenetic Sublineages of Mycobacterium tuberculosis Beijing Genotype in China.
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中国结核分枝杆菌北京基因型系统发育亚系的进化史和持续传播
DOI：
10.1038/srep34353
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发表时间：
2016-09-29
影响因子：
4.6
通讯作者：
Mokrousov I
中科院分区：
文献类型：
--
作者：
Yin QQ;Liu HC;Jiao WW;Li QJ;Han R;Tian JL;Liu ZG;Zhao XQ;Li YJ;Wan KL;Shen AD;Mokrousov I
北京基因型结核分枝杆菌起源于中国，在上个世纪经历了急剧的人口增长和全球传播。本研究采用高分辨率（24-MIRU-VNTR）和低分辨率、高阶（现代和古代亚谱系）标记对来自中国不同省份的北京结核分枝杆菌家族分离株进行基因分型。分子谱和整体和局部系统发育比较菌株表型和患者数据。在研究收集中观察到的系统地理模式表明，大尺度（而不是中/小尺度）距离仍然是结核分枝杆菌群体遗传分化的决定性因素之一。对当地收集的多样性和网络拓扑结构的分析似乎证实了最近关于北京基因型起源于中国南方的一个有趣的假设。将我们的结果置于欧亚背景下，表明北京基因型的重要俄罗斯B0/W148和亚洲/俄罗斯A0/94-32流行克隆的起源分别可以追溯到中国东北和西北地区。现代分离株在儿童中较高的聚集性和在任何亚谱系中都没有增加的耐多药率表明，与耐药性无关，但其他（例如推测，与毒力相关）特性是北京基因型现代亚谱系在中国进化最近的传播增强的基础。
Mycobacterium tuberculosis Beijing genotype originated in China and has undergone a dramatic population growth and global spread in the last century. Here, a collection of M. tuberculosis Beijing family isolates from different provinces across all China was genotyped by high-resolution (24-MIRU-VNTR) and low-resolution, high-rank (modern and ancient sublineages) markers. The molecular profiles and global and local phylogenies were compared to the strain phenotype and patient data. The phylogeographic patterns observed in the studied collection demonstrate that large-scale (but not middle/small-scale) distance remains one of the decisive factors of the genetic divergence of M. tuberculosis populations. Analysis of diversity and network topology of the local collections appears to corroborate a recent intriguing hypothesis about Beijing genotype originating in South China. Placing our results within the Eurasian context suggested that important Russian B0/W148 and Asian/Russian A0/94-32 epidemic clones of the Beijing genotype could trace their origins to the northeastern and northwestern regions of China, respectively. The higher clustering of the modern isolates in children and lack of increased MDR rate in any sublineage suggest that not association with drug resistance but other (e.g., speculatively, virulence-related) properties underlie an enhanced dissemination of the evolutionarily recent, modern sublineage of the Beijing genotype in China.
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影响因子：
64.8
作者：
Bos KI;Harkins KM;Herbig A;Coscolla M;Weber N;Comas I;Forrest SA;Bryant JM;Harris SR;Schuenemann VJ;Campbell TJ;Majander K;Wilbur AK;Guichon RA;Wolfe Steadman DL;Cook DC;Niemann S;Behr MA;Zumarraga M;Bastida R;Huson D;Nieselt K;Young D;Parkhill J;Buikstra JE;Gagneux S;Stone AC;Krause J
通讯作者：
Krause J
东亚南部起源以及结核分枝杆菌北京家族与汉族人的共同扩张。
DOI：
10.1073/pnas.1424063112
发表时间：
2015-06-30
影响因子：
11.1
作者：
Luo, Tao;Comas, Inaki;Gao, Qian
通讯作者：
Gao, Qian
影响因子：
30.8
作者：
Merker, Matthias;Blin, Camille;Wirth, Thierrv
通讯作者：
Wirth, Thierrv
影响因子：
30.8
作者：
Comas, Inaki;Borrell, Sonia;Roetzer, Andreas;Rose, Graham;Malla, Bijaya;Kato-Maeda, Midori;Galagan, James;Niemann, Stefan;Gagneux, Sebastien
通讯作者：
Gagneux, Sebastien
影响因子：
9.4
作者：
Kamerbeek, J;Schouls, L;vanEmbden, J
通讯作者：
vanEmbden, J