Transcriptomes of the B and T lineages compared by multiplatform microarray profiling.
Transcriptomes of the B and T lineages compared by multiplatform microarray profiling.
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DOI：
10.4049/jimmunol.1002695
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发表时间：
2011-03-01
期刊：
影响因子：
--
通讯作者：
Immunological Genome Project Consortium
中科院分区：
文献类型：
--
作者：
Painter MW;Davis S;Hardy RR;Mathis D;Benoist C;Immunological Genome Project Consortium
T and B lymphocytes are developmentally and functionally related cells of the immune system, representing the two major branches of adaptive immunity. Although originating from a common precursor, they play very different roles: T cells contribute to and drive cell-mediated immunity, while B cells secrete antibodies. Because of their functional importance and well-characterized differentiation pathways, T and B lymphocytes are ideal cell-types with which to understand how functional differences are encoded at the transcriptional level. Although there has been a great deal of interest in defining regulatory factors that distinguish T and B cells, a truly genome-wide view of the transcriptional differences between these two cells types has not yet been taken. To obtain a more global perspective of the transcriptional differences underlying T and B cells, we exploited the statistical power of combinatorial profiling on different microarray platforms, and the breadth of the Immunological Genome Project (ImmGen) gene-expression database, to generate robust differential signatures. We find that differential expression in T and B cells is pervasive, the majority of transcripts showing statistically significant differences. These distinguishing characteristics are acquired gradually, though all stages of B and T differentiation. On the other hand, very few T vs. B signature genes are uniquely expressed in these lineages, but are shared throughout immune cells.
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影响因子：
4.4
作者：
Mick, VE;Starr, TK;Hogquist, KA
通讯作者：
Hogquist, KA
影响因子：
4.4
作者：
Hoffmann, R;Bruno, L;Melchers, F
通讯作者：
Melchers, F
影响因子：
32.4
作者：
Pai, SY;Truitt, ML;Ho, IC
通讯作者：
Ho, IC
DOI：
10.1073/pnas.0808070105
发表时间：
2008-10-14
影响因子：
11.1
作者：
Venanzi, Emily S.;Melamed, Rachel;Benoist, Christophe
通讯作者：
Benoist, Christophe
影响因子：
4.4
作者：
Northrup, Daniel L.;Allman, David
通讯作者：
Allman, David