A tissue-engineered jellyfish with biomimetic propulsion.
A tissue-engineered jellyfish with biomimetic propulsion.
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DOI：
10.1038/nbt.2269
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发表时间：
2012-08
影响因子：
46.9
通讯作者：
中科院分区：
文献类型：
--
作者：
生物学形式和功能的逆向工程需要在几个时空和时间上进行层次设计。促进细胞自组织的化学微环境增强了概括工程中这种层次结构的能力生物系统。通过计算机模拟和实验设计，以匹配水母推进的关键确定剂，并通过定量模仿结构设计，中风运动学设计算法与身体绩效的基准相结合，这表明我们的策略广泛适用于肌肉机构或简单的生命形式，这些策略通常适用于生存。
Reverse engineering of biological form and function requires hierarchical design over several orders of space and time. Recent advances in the mechanistic understanding of biosynthetic compound materials, computer-aided design approaches in molecular synthetic biology and traditional soft robotics, and increasing aptitude in generating structural and chemical microenvironments that promote cellular self-organization have enhanced the ability to recapitulate such hierarchical architecture in engineered biological systems. Here we combined these capabilities in a systematic design strategy to reverse engineer a muscular pump. We report the construction of a freely swimming jellyfish from chemically dissociated rat tissue and silicone polymer as a proof of concept. The constructs, termed ‘medusoids’, were designed with computer simulations and experiments to match key determinants of jellyfish propulsion and feeding performance by quantitatively mimicking structural design, stroke kinematics and animal-fluid interactions. The combination of the engineering design algorithm with quantitative benchmarks of physiological performance suggests that our strategy is broadly applicable to reverse engineering of muscular organs or simple life forms that pump to survive.
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影响因子：
2.4
作者：
Huang AH;Farrell MJ;Mauck RL
通讯作者：
Mauck RL
影响因子：
--
作者：
Kaznessis, Yiannis N.
通讯作者：
Kaznessis, Yiannis N.
影响因子：
6.1
作者：
Grosberg A;Alford PW;McCain ML;Parker KK
通讯作者：
Parker KK
影响因子：
1.4
作者：
Chapman, DM
通讯作者：
Chapman, DM
影响因子：
2.4
作者：
Koehl, MAR
通讯作者：
Koehl, MAR