Body mass index is associated with biological CSF markers of core brain pathology of Alzheimer's disease.
Body mass index is associated with biological CSF markers of core brain pathology of Alzheimer's disease.
复制标题
DOI：
10.1016/j.neurobiolaging.2011.05.005
复制
发表时间：
2012-08
影响因子：
4.2
通讯作者：
Alzheimer's Disease Neuroimaging Initiative
中科院分区：
文献类型：
--
作者：
Ewers M;Schmitz S;Hansson O;Walsh C;Fitzpatrick A;Bennett D;Minthon L;Trojanowski JQ;Shaw LM;Faluyi YO;Vellas B;Dubois B;Blennow K;Buerger K;Teipel SJ;Weiner M;Hampel H;Alzheimer's Disease Neuroimaging Initiative
体重变化在衰老和阿尔茨海默病(AD)中很常见，尸检结果表明体重指数(BMI)较低与AD脑病理增加有关。在目前的多中心研究中，我们在751名活体受试者中测试了较低的BMI是否与较高的AD核心脑病理相关，这些受试者包括308名AD患者、296名遗忘性轻度认知障碍(MCI)患者和147名老年健康对照(HC)。根据脑脊液总tau和β-淀粉样蛋白(Aβ1-42)浓度的先验截断值，将受试者分为脑脊液生物标志物异常组(csf+)和无异常脑脊液组(csf−)。结果显示，脑脊液+组的体重指数显著低于脑脊液−组(F=27.7df=746p<；0.001)。脑脊液征象与诊断或载脂蛋白E基因型之间没有交互作用。总而言之，在痴呆和非痴呆的老年受试者中，较低的BMI预示着AD的病理，这是基于脑脊液的生物标志物评估的结果。
Weight changes are common in aging and Alzheimer’s disease (AD) and post-mortem findings suggested a relation between lower body mass index (BMI) and increased AD brain pathology. In the current multicenter study, we tested whether lower BMI is associated with higher core AD brain pathology as assessed by cerebrospinal fluid (CSF) based biological markers of AD in 751 living subjects: 308 patients with AD, 296 subjects with amnestic mild cognitive impairment (MCI), and 147 elderly healthy controls (HC). Based upon a priori cutoff values on CSF concentration of total tau and beta-amyloid (Aβ1-42), subjects were binarized into a group with abnormal CSF biomarker signature (CSF+) and those without (CSF−). Results showed that BMI was significantly lower in the CSF+ when compared to the CSF− group (F = 27.7, df = 746, p < 0.001). There was no interaction between CSF signature and diagnosis or ApoE genotype. In conclusion, lower BMI is indicative of AD pathology as assessed with CSF-based biomarkers in demented and non-demented elderly subjects.
登录
查看更多内容
影响因子：
--
作者：
Craft, Suzanne
通讯作者：
Craft, Suzanne
DOI：
10.1016/s0140-6736(20)32205-4
发表时间：
2021-04-24
期刊：
Lancet (London, England)
影响因子：
--
作者：
Scheltens P;De Strooper B;Kivipelto M;Holstege H;Chételat G;Teunissen CE;Cummings J;van der Flier WM
通讯作者：
van der Flier WM
影响因子：
9.9
作者：
Buchman, A. S.;Schneider, J. A.;Bennett, D. A.
通讯作者：
Bennett, D. A.
影响因子：
3.8
作者：
DOTY, RL;REYES, PF;GREGOR, T
通讯作者：
GREGOR, T
DOI：
10.1111/j.1532-5415.2004.52174.x
发表时间：
2004-04-01
影响因子：
6.3
作者：
Ferrucci, L;Guralnik, JM;Walston, JD
通讯作者：
Walston, JD