Calcitonin gene-related peptide alters the firing rates of hypothalamic temperature sensitive and insensitive neurons.
Calcitonin gene-related peptide alters the firing rates of hypothalamic temperature sensitive and insensitive neurons.
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DOI：
10.1186/1471-2202-9-64
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发表时间：
2008-07-11
期刊：
影响因子：
2.4
通讯作者：
Griffin JD
中科院分区：
文献类型：
--
作者：
Braasch DC;Deegan EM;Grimm ER;Griffin JD
体温的短暂高热变化与内源性激素降钙素基因相关肽（CGRP）有关，它可以增加交感神经激活和代谢产热。最近的研究表明，这些中枢介导的反应可能是由于CGRP依赖性的变化，温度调节神经元的活动在视前区和前区的下丘脑（POAH）。用组织切片法记录成年雄性大鼠POAH神经元对温度和CGRP（10 μM）的反应。根据放电率随温度变化的斜率，神经元分为温敏神经元和温不敏神经元。所有的温敏神经元对CGRP的反应都是放电频率显著降低。虽然CGRP没有改变一些温度不敏感神经元的放电率，但反应神经元的放电率显示出增加。相对于当前的体温调节控制模型，这些CGRP依赖性的放电率变化将导致体温过高。这表明POAH中的温敏神经元和温度不敏感神经元都可能在产生这种体温升高中起作用。
Transient hyperthermic shifts in body temperature have been linked to the endogenous hormone calcitonin gene-related peptide (CGRP), which can increase sympathetic activation and metabolic heat production. Recent studies have demonstrated that these centrally mediated responses may result from CGRP dependent changes in the activity of thermoregulatory neurons in the preoptic and anterior regions of the hypothalamus (POAH). Using a tissue slice preparation, we recorded the single-unit activity of POAH neurons from the adult male rat, in response to temperature and CGRP (10 μM). Based on the slope of firing rate as a function of temperature, neurons were classified as either warm sensitive or temperature insensitive. All warm sensitive neurons responded to CGRP with a significant decrease in firing rate. While CGRP did not alter the firing rates of some temperature insensitive neurons, responsive neurons showed an increase in firing rate. With respect to current models of thermoregulatory control, these CGRP dependent changes in firing rate would result in hyperthermia. This suggests that both warm sensitive and temperature insensitive neurons in the POAH may play a role in producing this hyperthermic shift in temperature.
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影响因子：
4.8
作者：
Aiyar, N;Rand, K;Li, Y
通讯作者：
Li, Y
影响因子：
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DEAN, JB;BOULANT, JA
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BOULANT, JA
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5.5
作者：
BOULANT, JA;HARDY, JD
通讯作者：
HARDY, JD
影响因子：
3.2
作者：
HERBISON, AE
通讯作者：
HERBISON, AE
影响因子：
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作者：
KELSO, SR;PERLMUTTER, MN;BOULANT, JA
通讯作者：
BOULANT, JA