PEGylated nanographene oxide for delivery of water-insoluble cancer drugs.
PEGylated nanographene oxide for delivery of water-insoluble cancer drugs.
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DOI：
10.1021/ja803688x
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发表时间：
2008-08-20
影响因子：
15
通讯作者：
Dai, Hongjie
中科院分区：
文献类型：
--
作者：
Liu, Zhuang;Robinson, Joshua T.;Sun, Xiaoming;Dai, Hongjie
众所周知，许多有效的芳香药物是不溶于水的，这阻碍了它们用于疾病治疗。在这项工作中，我们功能化纳米氧化石墨烯（NGO），一种新型的石墨材料，与支化聚乙二醇（PEG），以获得生物相容性NGO-PEG共轭物稳定在各种生物溶液中，并使用它们连接疏水性芳香族分子，包括喜树碱（CPT）类似物，SN 38通过π-π堆积非共价。所得的NGO-PEG-SN 38复合物表现出优异的水溶性，同时保持其与有机溶剂中的游离SN 38分子类似的高癌细胞杀伤效力。NGO-PEG-SN 38的功效远高于伊立替康（CPT-11），伊立替康是FDA批准的用于治疗结肠癌的水溶性SN 38前药。我们的研究结果表明，石墨烯是一类新型材料，有望用于生物应用，包括未来用各种芳香族低溶解度药物进行体内癌症治疗。
It is known that many potent, often aromatic drugs are water insoluble, which has hampered their use for disease treatment. In this work, we functionalized nano-graphene oxide (NGO), a novel graphitic material, with branched polyethylene glycol (PEG) to obtain a biocompatible NGO-PEG conjugate stable in various biological solutions, and used them for attaching hydrophobic aromatic molecules including a camptothecin (CPT) analog, SN38 non-covalently via π-π stacking. The resulting NGO-PEG-SN38 complex exhibited excellent water solubility while maintaining its high cancer cell killing potency similar to that of the free SN38 molecules in organic solvents. The efficacy of NGO-PEG-SN38 was far higher than that of irinotecan (CPT-11), a FDA approved water soluble SN38 prodrug used for the treatment of colon cancer. Our results showed that graphene is a novel class of material promising for biological applications including future in vivo cancer treatment with various aromatic, low-solubility drugs.
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影响因子：
64.8
作者：
Stankovich, Sasha;Dikin, Dmitriy A.;Ruoff, Rodney S.
通讯作者：
Ruoff, Rodney S.
影响因子：
15
作者：
HUMMERS, WS;OFFEMAN, RE
通讯作者：
OFFEMAN, RE
影响因子：
15
作者：
Kam, NWS;Dai, HJ
通讯作者：
Dai, HJ
DOI：
10.1073/pnas.0707654105
发表时间：
2008-02-05
影响因子：
11.1
作者：
Liu, Zhuang;Davis, Corrine;Dai, Hongjie
通讯作者：
Dai, Hongjie
影响因子：
41.2
作者：
Geim, A. K.;Novoselov, K. S.
通讯作者：
Novoselov, K. S.