Environmental enrichment restores neurogenesis and rapid acquisition in aged rats.
Environmental enrichment restores neurogenesis and rapid acquisition in aged rats.
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DOI：
10.1016/j.neurobiolaging.2012.05.023
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发表时间：
2013-01
影响因子：
4.2
通讯作者：
Ormerod BK
中科院分区：
文献类型：
--
作者：
Speisman RB;Kumar A;Rani A;Pastoriza JM;Severance JE;Foster TC;Ormerod BK
应对不断增长的老龄化人口中认知能力下降的战略至关重要。我们测试了环境丰富是否可以逆转年龄受损的快速空间搜索策略习得，同时伴随着大鼠的海马神经发生。将青年(5~8mo)和老年(20~22mo)雄性Fischer 344只大鼠配对饲养，或单独饲养(青年各7只，老年各7只)。5周后，隐藏平台试验(5块3次试验；15M IBI)、探针试验和可见平台试验(5块3次试验；15M IBI)在水迷宫中开始。实验结束后1周，每天给大鼠灌胃5次溴脱氧尿嘧啶核苷(BrdU，50 mg/kg，ip)。4周后进行注射和灌流，以量化神经发生。虽然年轻大鼠的表现优于老年大鼠，但在所有行为指标上，老年富足大鼠的表现都好于老年单独饲养的大鼠。神经发生随着年龄的增长而减少，但无论年龄大小，富集物都能提高新细胞的存活率。在老年大鼠的快速水迷宫任务中，新的神经元数量与行为测量之间的新相关性表明，环境的丰富提高了它们在神经发生过程中快速获取和灵活使用空间信息的能力。
Strategies combatting cognitive decline among the growing aging population are vital. We tested whether environmental enrichment could reverse age-impaired rapid spatial search strategy acquisition concomitantly with hippocampal neurogenesis in rats. Young (5–8 mo) and aged (20–22 mo) male Fischer 344 rats were pair-housed and exposed to environmental enrichment (n=7 young, 9 aged) or housed individually (n=7 young, 7 aged) for ten weeks. After five weeks, hidden platform trials (5 blocks of 3 trials; 15m IBI), a probe trial, and then visible platform trials (5 blocks of 3 trials; 15m IBI) commenced in the water maze. One week after testing, rats were given 5 daily bromodeoxyuridine (BrdU, 50mg/kg; i.p.) injections and perfused 4 weeks later to quantify neurogenesis. Although young rats outperformed aged rats, aged enriched rats outperformed aged individually-housed rats on all behavioral measures. Neurogenesis decreased with age but enrichment enhanced new cell survival, regardless of age. The novel correlation between new neuron number and behavioral measures obtained in a rapid water maze task among aged rats, suggests that environmental enrichment increases their ability to rapidly acquire and flexibly use spatial information along with neurogenesis.
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影响因子：
82.9
作者：
Eriksson, PS;Perfilieva, E;Gage, FH
通讯作者：
Gage, FH
影响因子：
3.3
作者：
Driscoll, I.;Howard, S. R.;Sutherland, R. J.
通讯作者：
Sutherland, R. J.
DOI：
10.1073/pnas.0809650106
发表时间：
2009-02-24
影响因子：
11.1
作者：
Dalla, Christina;Papachristos, Efstathios B.;Shors, Tracey J.
通讯作者：
Shors, Tracey J.
影响因子：
2.4
作者：
Aizawa, Ken;Ageyama, Naohide;Hisatsune, Tatsuhiro
通讯作者：
Hisatsune, Tatsuhiro
影响因子：
5.3
作者：
Drapeau, Elodie;Montaron, Marie-Francoise;Abrous, Djoher Nora
通讯作者：
Abrous, Djoher Nora