Dissemination of Mycobacterium abscessus via global transmission networks.
Dissemination of Mycobacterium abscessus via global transmission networks.
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DOI：
10.1038/s41564-021-00963-3
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发表时间：
2021-10
影响因子：
28.3
通讯作者：
Parkhill J
中科院分区：
文献类型：
--
作者：
Ruis C;Bryant JM;Bell SC;Thomson R;Davidson RM;Hasan NA;van Ingen J;Strong M;Floto RA;Parkhill J
脓肿分枝杆菌是一种耐多药的非结核分枝杆菌，已成为影响囊性纤维化（CF）患者的主要病原体。虽然最初被认为是独立于环境获得的，但大多数个体感染的是几种优势循环克隆（dcc）中的一种，这表明存在脓肿分枝杆菌的全球传播网络。目前尚不清楚这些克隆是如何以及何时出现并在全球传播的。在此，我们使用进化分析的方法，从有和没有CF的个体分离株中重建了dcc的种群历史、时空分布和最近的传播网络。我们证明了在20世纪60年代6个不相关的dcc的同步扩张，这一时期与CF治疗和生存率的重大变化有关。由于罕见的洲际传播事件，这些克隆中的每一个都在全球传播。我们发现，dcc，而不是环境获得性分离株，表现出特定的吸烟相关突变特征，目前的传播网络包括患有和不患有CF的个体。因此，我们提出，dcc最初出现在非CF人群中，但随后被放大并在CF群体中传播。虽然CF个体可能是最宽容的宿主，但非CF个体继续在传播网络中发挥关键作用，并可能促进长距离传播。在这篇文章中，作者对脓疡分枝杆菌临床分离株进行了进化分析，并报告了在非囊性纤维化（CF）个体中出现显性循环克隆（DCCs），随后在CF群落中扩增。
Mycobacterium abscessus, a multidrug-resistant nontuberculous mycobacterium, has emerged as a major pathogen affecting people with cystic fibrosis (CF). Although originally thought to be acquired independently from the environment, most individuals are infected with one of several dominant circulating clones (DCCs), indicating the presence of global transmission networks of M. abscessus. How and when these clones emerged and spread globally is unclear. Here, we use evolutionary analyses of isolates from individuals both with and without CF to reconstruct the population history, spatiotemporal spread and recent transmission networks of the DCCs. We demonstrate synchronous expansion of six unrelated DCCs in the 1960s, a period associated with major changes in CF care and survival. Each of these clones has spread globally as a result of rare intercontinental transmission events. We show that the DCCs, but not environmentally acquired isolates, exhibit a specific smoking-associated mutational signature and that current transmission networks include individuals both with and without CF. We therefore propose that the DCCs initially emerged in non-CF populations but were then amplified and spread through the CF community. While individuals with CF are probably the most permissive host, non-CF individuals continue to play a key role in transmission networks and may facilitate long-distance transmission. In this Article, the authors perform evolutionary analyses of M. abscessus clinical isolates and report the emergence of dominant circulating clones (DCCs) in non-cystic fibrosis (CF) individuals followed by amplification in the CF community.
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DOI：
10.1164/rccm.201111-2016oc
发表时间：
2012-04-15
影响因子：
24.7
作者：
Adjemian, Jennifer;Olivier, Kenneth N.;Prevots, D. Rebecca
通讯作者：
Prevots, D. Rebecca
影响因子：
10
作者：
Floto RA;Olivier KN;Saiman L;Daley CL;Herrmann JL;Nick JA;Noone PG;Bilton D;Corris P;Gibson RL;Hempstead SE;Koetz K;Sabadosa KA;Sermet-Gaudelus I;Smyth AR;van Ingen J;Wallace RJ;Winthrop KL;Marshall BC;Haworth CS;US Cystic Fibrosis Foundation and European Cystic Fibrosis Society
通讯作者：
US Cystic Fibrosis Foundation and European Cystic Fibrosis Society
DOI：
10.1126/science.abb8699
发表时间：
2021-04-30
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bryant JM;Brown KP;Burbaud S;Everall I;Belardinelli JM;Rodriguez-Rincon D;Grogono DM;Peterson CM;Verma D;Evans IE;Ruis C;Weimann A;Arora D;Malhotra S;Bannerman B;Passemar C;Templeton K;MacGregor G;Jiwa K;Fisher AJ;Blundell TL;Ordway DJ;Jackson M;Parkhill J;Floto RA
通讯作者：
Floto RA
影响因子：
24.3
作者：
Burgel, Pierre-Regis;Bellis, Gil;Elborn, J. Stuart
通讯作者：
Elborn, J. Stuart
影响因子：
4.6
作者：
Brunel, Shan F.;Willment, Janet A.;Warris, Adilia
通讯作者：
Warris, Adilia