Smoking cessation and mortality among middle-aged and elderly Chinese in Singapore: the Singapore Chinese Health Study.
Smoking cessation and mortality among middle-aged and elderly Chinese in Singapore: the Singapore Chinese Health Study.
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DOI：
10.1136/tobaccocontrol-2011-050106
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发表时间：
2013-07
期刊：
影响因子：
5.2
通讯作者：
Koh, Woon-Puay
中科院分区：
文献类型：
--
作者：
Lim, Sin How;Tai, Bee Choo;Yuan, Jian-Min;Yu, Mimi C.;Koh, Woon-Puay
这项研究确定了与长期戒烟相比，近期戒烟是否可以降低与吸烟相关的死亡风险。对来自新加坡华人健康研究的数据进行了分析（n=48 251），该研究是一项针对新加坡中老年华人的队列研究。吸烟状况在1993年至1998年期间进行了评估，并在1999年至2004年期间进行了重新评估。参与者被分为从不吸烟者，长期戒烟者（招募前戒烟，平均17.0年），新戒烟者（招募和第二次面试之间戒烟，平均4.3年）和当前吸烟者。死亡率是通过与全国死亡登记处联系确定的。经过平均8.1年的随访，截至2009年12月31日，共有6003例死亡。与当前吸烟者相比，新戒烟者总死亡率的校正HR（95%CI）为0.84（0.76至0.94），长期戒烟者为0.61（0.56至0.67），从不吸烟者为0.49（0.46至0.53）。新戒烟者肺癌死亡率降低24%（HR：0.76，95% CI 0.57 - 1.00），长期戒烟者降低56%（HR：0.44，95% CI 0.35 - 0.57）。新戒烟者（HR：0.84，95% CI 0.66 - 1.08）和长期戒烟者（HR：0.63，95% CI 0.52 - 0.77）的冠心病死亡风险降低，尽管由于心血管死亡人数相对较少，新戒烟者的结果具有边缘意义。长期戒烟者的慢性肺病死亡风险降低，但新戒烟者的风险增加。戒烟5年内可显著降低总死亡率的风险，特别是肺癌死亡率。
This study determines if recent smoking cessation, compared with long-term cessation, can reduce mortality risk associated with smoking. Data from the Singapore Chinese Health Study, a cohort study of middle-aged and elderly Chinese in Singapore, were analysed (n=48 251). Smoking status was evaluated at recruitment between 1993 and 1998 and reassessed between 1999 and 2004. Participants were classified as never-smokers, long-term quitters (quit before recruitment, mean 17.0 years), new quitters (quit between recruitment and second interview, mean 4.3 years) and current smokers. Mortality was ascertained by linkage with the nationwide death registry. After a mean follow-up of 8.1 years, 6003 deaths had occurred by 31 December 2009. Compared with current smokers, the adjusted HR (95% CI) for total mortality was 0.84 (0.76 to 0.94) for new quitters, 0.61 (0.56 to 0.67) for long-term quitters and 0.49 (0.46 to 0.53) for never-smokers. New quitters had 24% reduction in lung cancer mortality (HR: 0.76, 95% CI 0.57 to 1.00) and long-term quitters had 56% reduction (HR: 0.44, 95% CI 0.35 to 0.57). Risk for coronary heart disease mortality was reduced in new quitters (HR: 0.84, 95% CI 0.66 to 1.08) and long-term quitters (HR: 0.63, 95% CI 0.52 to 0.77), although the result for new quitters was of borderline significance due to relatively small number of cardiovascular deaths. Risk for chronic pulmonary disease mortality was reduced in long-term quitters but increased in new quitters. Significant reduction in risk of total mortality, specifically for lung cancer mortality, can be achieved within 5 years of smoking cessation.
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影响因子：
5.2
作者：
Barzi, F.;Huxley, R.;Woodward, M.
通讯作者：
Woodward, M.
影响因子：
24.3
作者：
Godtfredsen, N. S.;Lam, T. H.;Vestbo, J.
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影响因子：
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作者：
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通讯作者：
Kiyohara, Yutaka
影响因子：
5
作者：
Iso, H;Date, C;Tamakoshi, A
通讯作者：
Tamakoshi, A
影响因子：
5.6
作者：
Lam, TH;He, Y;Li, LS
通讯作者：
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