A middle ground where executive control meets semantics: the neural substrates of semantic control are topographically sandwiched between the multiple-demand and default-mode systems.
A middle ground where executive control meets semantics: the neural substrates of semantic control are topographically sandwiched between the multiple-demand and default-mode systems.
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DOI：
10.1093/cercor/bhac358
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发表时间：
2023-04-04
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影响因子：
--
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语义控制是对有意义的表征进行操作的能力，选择性地专注于意义的某些方面，而基于一个人的行为目标有目的地忽略其他方面。这种能力对于理解比喻性/模糊性语言尤其重要。目前尚不清楚为什么以及如何参与语义控制的区域似乎可靠地与联合皮层中其他功能专门化区域并列，引发了对地形和功能之间关系的猜测。我们研究了这个问题的特征如何语义控制区拓扑关系的默认模式网络（与记忆和抽象认知）和多需求网络（与执行控制）。从地形上看，我们建立了语义控制区夹在默认模式和多需求网络，形成了一个有序的安排，观察在个人和群体水平。在功能上，语义控制区表现出“混合”的反应，融合了认知要求的操作（多需求）和有意义的表示（默认模式）到一个域特定的偏好，有意义的表示上的困难操作的通用偏好。当投射到人类连接体的主梯度上时，语义控制的神经活动与视觉空间控制的神经活动呈现出鲁棒分离的轨迹，这意味着语义控制在从感觉到认知的功能转换中扮演不同的角色。我们讨论了为什么语义控制区的混合功能配置文件可能会导致他们的中间地形位置的皮层。
Semantic control is the capability to operate on meaningful representations, selectively focusing on certain aspects of meaning while purposefully ignoring other aspects based on one’s behavioral aim. This ability is especially vital for comprehending figurative/ambiguous language. It remains unclear why and how regions involved in semantic control seem reliably juxtaposed alongside other functionally specialized regions in the association cortex, prompting speculation about the relationship between topography and function. We investigated this issue by characterizing how semantic control regions topographically relate to the default-mode network (associated with memory and abstract cognition) and multiple-demand network (associated with executive control). Topographically, we established that semantic control areas were sandwiched by the default-mode and multi-demand networks, forming an orderly arrangement observed both at the individual and group level. Functionally, semantic control regions exhibited “hybrid” responses, fusing generic preferences for cognitively demanding operation (multiple-demand) and for meaningful representations (default-mode) into a domain-specific preference for difficult operation on meaningful representations. When projected onto the principal gradient of human connectome, the neural activity of semantic control showed a robustly dissociable trajectory from visuospatial control, implying different roles in the functional transition from sensation to cognition. We discuss why the hybrid functional profile of semantic control regions might result from their intermediate topographical positions on the cortex.
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影响因子：
5.7
作者：
Jackson RL
通讯作者：
Jackson RL
DOI：
10.1093/cercor/bhv003
发表时间：
2015-11
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Jackson RL;Hoffman P;Pobric G;Lambon Ralph MA
通讯作者：
Lambon Ralph MA
影响因子：
5.3
作者：
Chiou, Rocco;Ralph, Matthew A. Lambon
通讯作者：
Ralph, Matthew A. Lambon
DOI：
10.1093/cercor/bhab362
发表时间：
2022-06-07
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
通讯作者：
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影响因子：
4.3
作者：
Jefferies, Elizabeth;Hoffman, Paul;Ralph, Matthew A. Lambon
通讯作者：
Ralph, Matthew A. Lambon