Positive Selection and Horizontal Gene Transfer in the Genome of a Male-Killing Wolbachia.
Positive Selection and Horizontal Gene Transfer in the Genome of a Male-Killing Wolbachia.
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杀雄沃尔巴克氏体基因组的正选择与水平基因转移。
DOI：
10.1093/molbev/msab303
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发表时间：
2022-01-07
影响因子：
10.7
通讯作者：
Perlmutter JI
中科院分区：
文献类型：
--
作者：
Hill T;Unckless RL;Perlmutter JI
沃尔巴克氏体是一种广泛分布的细菌内共生体，其中一些菌株可以劫持或操纵节肢动物宿主的繁殖。杀死雄性就是这样一种操纵，在这种操纵中，这些母系传播的细菌通过消除与儿子争夺稀缺资源的竞争，部分地使幸存的女儿受益。尽管以前发现了微生物性别比例扭曲的有趣基因组特征，但男性杀手的群体基因组学在很大程度上仍然没有特征。在这里，我们发现了几个独特的功能的基因组和人口基因组学的四个亚利桑那州人口的男性杀死沃尔巴克氏体菌株，wInn，感染蘑菇喂养的果蝇。我们首先将wInn基因组与果蝇宿主的其他密切相关的Wolbachia基因组在基因组内容方面进行了比较，并确认wInn基因组在总体基因内容上与感染D.黑腹果蝇然而，它也包含许多独特的基因和重复的遗传元件，表明wInn和非果蝇真核生物之间的横向基因转移。我们还发现，在符合文献先例，基因在沃尔巴克氏体原噬菌体和Octomom区域正选择。在正选择下的所有基因中，许多也显示出最近沃尔巴克氏体共生体基因组之间水平转移的证据。这些动力学的选择和水平基因转移的基因组中的几个沃尔巴克氏体菌株和不同的宿主物种可能是重要的潜在因素沃尔巴克氏体的成功作为一个男性杀手的分歧的宿主物种。
Wolbachia are a genus of widespread bacterial endosymbionts in which some strains can hijack or manipulate arthropod host reproduction. Male killing is one such manipulation in which these maternally transmitted bacteria benefit surviving daughters in part by removing competition with the sons for scarce resources. Despite previous findings of interesting genome features of microbial sex ratio distorters, the population genomics of male-killers remain largely uncharacterized. Here, we uncover several unique features of the genome and population genomics of four Arizonan populations of a male-killing Wolbachia strain, wInn, that infects mushroom-feeding Drosophila innubila. We first compared the wInn genome with other closely related Wolbachia genomes of Drosophila hosts in terms of genome content and confirm that the wInn genome is largely similar in overall gene content to the wMel strain infecting D. melanogaster. However, it also contains many unique genes and repetitive genetic elements that indicate lateral gene transfers between wInn and non-Drosophila eukaryotes. We also find that, in line with literature precedent, genes in the Wolbachia prophage and Octomom regions are under positive selection. Of all the genes under positive selection, many also show evidence of recent horizontal transfer among Wolbachia symbiont genomes. These dynamics of selection and horizontal gene transfer across the genomes of several Wolbachia strains and diverse host species may be important underlying factors in Wolbachia’s success as a male-killer of divergent host species.
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影响因子：
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作者：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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