Long noncoding RNAs: an emerging link between gene regulation and nuclear organization.
Long noncoding RNAs: an emerging link between gene regulation and nuclear organization.
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DOI：
10.1016/j.tcb.2014.08.009
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发表时间：
2014-11
影响因子：
19
通讯作者：
Guttman, Mitchell
中科院分区：
文献类型：
--
作者：
Quinodoz, Sofia;Guttman, Mitchell
哺乳动物基因组编码数以千计的长链非编码rna (lncrna)，它们在多种生物过程中发挥着重要作用。作为一类，lncrna通常富集于细胞核中，特别是染色质相关部分。与其定位一致，许多lncrna参与基因表达调控和形成三维核组织。在这里，我们讨论了许多核保留lncrna可以与各种染色质调节蛋白相互作用并将其招募到DNA上的特定位点以调节基因表达的证据。此外，我们还讨论了特定lncrna在形成核组织中的作用及其新兴机制。基于这些例子，我们提出了一个模型来解释lncRNAs如何塑造核组织的各个方面来调节基因表达。
Mammalian genomes encode thousands of long non-coding RNAs (lncRNAs) that play important roles in diverse biological processes. As a class, lncRNAs are generally enriched in the nucleus and specifically within the chromatin-associated fraction. Consistent with their localization, many lncRNAs have been implicated in the regulation of gene expression and in shaping three-dimensional nuclear organization. Here, we discuss the evidence that many nuclear-retained lncRNAs can interact with various chromatin regulatory proteins and recruit them to specific sites on DNA to regulate gene expression. Furthermore, we discuss the role of specific lncRNAs in shaping nuclear organization and their emerging mechanisms. Based on these examples, we propose a model that explains how lncRNAs may shape aspects of nuclear organization to regulate gene expression.
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影响因子：
16
作者：
Cifuentes-Rojas, Catherine;Hernandez, Alfredo J.;Sarma, Kavitha;Lee, Jeannie T.
通讯作者：
Lee, Jeannie T.
影响因子：
7.3
作者：
Atchison ML
通讯作者：
Atchison ML
DOI：
10.1126/science.1240925
发表时间：
2013-08-16
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Carpenter S;Aiello D;Atianand MK;Ricci EP;Gandhi P;Hall LL;Byron M;Monks B;Henry-Bezy M;Lawrence JB;O'Neill LA;Moore MJ;Caffrey DR;Fitzgerald KA
通讯作者：
Fitzgerald KA
影响因子：
10.5
作者：
Cabili, Moran N.;Trapnell, Cole;Rinn, John L.
通讯作者：
Rinn, John L.
影响因子：
7.8
作者：
Clemson, CM;McNeil, JA;Willard, HF;Lawrence, JB
通讯作者：
Lawrence, JB