Chronic Stress That Changed Intestinal Permeability and Induced Inflammation Was Restored by Estrogen.
Chronic Stress That Changed Intestinal Permeability and Induced Inflammation Was Restored by Estrogen.
复制标题
改变肠道渗透性和诱导炎症的慢性应激可通过雌激素恢复。
DOI：
10.3390/ijms241612822
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发表时间：
2023-08-15
影响因子：
5.6
通讯作者：
Dong, Yulan
中科院分区：
文献类型：
--
作者：
Li, Yuanyuan;Wan, Huayun;Ma, Ruiqin;Liu, Tianya;Chen, Yaoxing;Dong, Yulan
Chronic psychological stress affects the health of humans and animals (especially females or pregnant bodies). In this study, a stress-induced model was established by placing eight-week-old female and pregnant mice in centrifuge tubes for 4 h to determine whether chronic stress affects the intestinal mucosal barrier and microbiota composition of pregnant mice. Compared with the control group, we found that norepinephrine (NE), corticosterone (CORT), and estradiol (E2) in plasma increased significantly in the stress group. We then observed a decreased down-regulation of anti-inflammatory cytokines and up-regulation of pro-inflammatory cytokines, which resulted in colonic mucosal injury, including a reduced number of goblet cells, proliferating cell nuclear antigen-positive cells, caspase-3, and expression of tight junction mRNA and protein. Moreover, the diversity and richness of the colonic microbiota decreased in pregnant mice. Bacteroidetes decreased, and pernicious bacteria were markedly increased. At last, we found E2 protects the intestinal epithelial cells after H2O2 treatment. Results suggested that 25 pg/mL E2 provides better protection for intestinal barrier after chronic stress, which greatly affected the intestinal mucosal barrier and altered the colonic microbiota composition.
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影响因子：
11.4
作者：
Bellanti F;Matteo M;Rollo T;De Rosario F;Greco P;Vendemiale G;Serviddio G
通讯作者：
Serviddio G
影响因子：
6.7
作者：
Christian, Lisa M.
通讯作者：
Christian, Lisa M.
影响因子：
2.3
作者：
Cutolo, M;Wilder, RL
通讯作者：
Wilder, RL
影响因子：
6.6
作者：
KESSLER, RC;MCGONAGLE, KA;NELSON, CB
通讯作者：
NELSON, CB
影响因子：
8.7
作者：
Bain CC;Mowat AM
通讯作者：
Mowat AM