Prescriptions of traditional Chinese medicine are specific to cancer types and adjustable to temperature changes.
Prescriptions of traditional Chinese medicine are specific to cancer types and adjustable to temperature changes.
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DOI：
10.1371/journal.pone.0031648
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Wang SC
中科院分区：
文献类型：
--
作者：
Chiu PH;Hsieh HY;Wang SC
具有特定分子靶点的靶向癌症疗法改善了放疗和化疗的副作用问题，也指向了个性化医疗的发展。针对多种致癌途径的药物组合可能更有成效。两千年来，传统中医一直在为个性化医疗定制草药混合物。系统地研究癌症的中医方药规律是有价值的。我们分析了2007年台湾30种癌症的187，230张中药处方，这是从全民健康保险报销数据库（台湾）收集的一年的价值。我们发现，一个中医癌症处方平均由两个配方和四种草药组成。我们发现，中药配方和中药配方中的百分比重量遵循齐普夫定律，指数约为0.6。治疗良性肿瘤的中药方剂Zipf指数大于治疗恶性肿瘤的中药方剂。此外，我们还表明，通过方药加权组合，中药处方不仅对肿瘤的恶性程度有特异性，而且对恶性肿瘤的起源部位也有特异性。从癌症常用方剂的组方和药性的作用，可以提出癌症属于中医学的“温煦瘀滞”证，提示抗炎药是预防和治疗癌症的有效方法。我们发现，中医药纳入相关配方的处方，以癌症患者的继发性发病率。我们比较了不同季节的中医处方，并确定温度作为环境因素，与台湾中医处方的变化。肺癌患者是气温下降时调整处方的患者之一。我们的研究结果为中医癌症治疗提供了见解，有助于现代西医和中医之间的对话，以更好地治疗癌症。
Targeted cancer therapies, with specific molecular targets, ameliorate the side effect issue of radiation and chemotherapy and also point to the development of personalized medicine. Combination of drugs targeting multiple pathways of carcinogenesis is potentially more fruitful. Traditional Chinese medicine (TCM) has been tailoring herbal mixtures for individualized healthcare for two thousand years. A systematic study of the patterns of TCM formulas and herbs prescribed to cancers is valuable. We analysed a total of 187,230 TCM prescriptions to 30 types of cancer in Taiwan in 2007, a year's worth of collection from the National Health Insurance reimbursement database (Taiwan). We found that a TCM cancer prescription consists on average of two formulas and four herbs. We show that the percentage weights of TCM formulas and herbs in a TCM prescription follow Zipf's law with an exponent around 0.6. TCM prescriptions to benign neoplasms have a larger Zipf's exponent than those to malignant cancers. Furthermore, we show that TCM prescriptions, via weighted combination of formulas and herbs, are specific to not only the malignancy of neoplasms but also the sites of origins of malignant cancers. From the effects of formulas and natures of herbs that were heavily prescribed to cancers, that cancers are a ‘warm and stagnant’ syndrome in TCM can be proposed, suggesting anti-inflammatory regimens for better prevention and treatment of cancers. We show that TCM incorporated relevant formulas to the prescriptions to cancer patients with a secondary morbidity. We compared TCM prescriptions made in different seasons and identified temperatures as the environmental factor that correlates with changes in TCM prescriptions in Taiwan. Lung cancer patients were among the patients whose prescriptions were adjusted when temperatures drop. The findings of our study provide insight to TCM cancer treatment, helping dialogue between modern western medicine and TCM for better cancer care.
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DOI：
10.1093/ecam/neq050
发表时间：
2011
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Hsieh HY;Chiu PH;Wang SC
通讯作者：
Wang SC
影响因子：
8.6
作者：
Furusawa, C;Kaneko, K
通讯作者：
Kaneko, K
DOI：
10.1093/ecam/neh140
发表时间：
2005-12
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Patwardhan B;Warude D;Pushpangadan P;Bhatt N
通讯作者：
Bhatt N
影响因子：
56.9
作者：
Axtell, RL
通讯作者：
Axtell, RL
影响因子：
7.6
作者：
Sung, JJY;Leung, WK;Chan, FKL
通讯作者：
Chan, FKL