Cognition, depression, fatigue, and quality of life in primary Sjögren's syndrome: correlations.
Cognition, depression, fatigue, and quality of life in primary Sjögren's syndrome: correlations.
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DOI：
10.1002/brb3.586
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发表时间：
2016-12
影响因子：
3.1
通讯作者：
Cetinkaya, Rumeysa
中科院分区：
文献类型：
--
作者：
Kocer, Belgin;Tezcan, Mehmet Engin;Batur, Hale Zeynep;Haznedaroglu, Seminur;Goker, Berna;Irkec, Ceyla;Cetinkaya, Rumeysa
本研究的目的是调查原发性干燥综合征 (PSS) 中观察到的认知功能障碍的患病率和模式，并检查认知能力、抑郁、疲劳和生活质量之间的关系。 32 名 PSS 受试者与 19 名健康对照者进行了综合神经心理学、抑郁、疲劳、健康状况和日常生活活动测试的比较。与健康对照组相比，PSS 患者在时钟绘图、COWAT、节奏听觉串行加法测试 (PASAT)、无色单词阅读 (Stroop1) 和识别颜色 (Stroop2)、STROOP 测试模式、SDLT、听觉语言学习测试 (AVLT)、即时和长期言语记忆、本顿线方向判断测试 (BJLOT) 以及所有 RCFT 模式中的表现均较低（p < .05）。据观察，与健康对照组相比，PSS 病例的抑郁频率增加、疲劳严重程度增加、健康状况受损以及生活质量下降 (p < .05)。所有抑郁、疲劳严重程度和生活质量测试均显示出相互之间显着的正相关性 (p < .05)。观察到时钟绘图与 SF-36-BP (p = .031, r = −.382) 和 SF-36-GH (p = .027, r = −.392) 之间存在显着负相关。 Clock Drawing、PASAT 和 AVLT 是非常有用的测试，可确定亚临床和临床认知功能障碍，以评估 PSS 患者的注意力、信息处理速度、执行功能以及短期和长期语言记忆。抑郁和疲劳可能不会影响神经心理学测试的表现。
The aim of the present study was to investigate the prevalence and pattern of cognitive dysfunction observed in primary Sjögren's syndrome (PSS) and to examine the relationships between cognitive abilities, depression, fatigue, and quality of life. Thirty‐two subjects with PSS were compared with 19 healthy controls on comprehensive neuropsychological, depression, fatigue, health state, and daily‐life activities tests. There was low performance in Clock Drawing, COWAT, Paced Auditory Serial Addition Test (PASAT), Colorless Word Reading (Stroop1) and Recognizing Colors (Stroop2) Patterns of STROOP test, SDLT, Auditory–Verbal Learning Test (AVLT), immediate and long‐term verbal memory, Benton Judgment of Line Orientation Test (BJLOT), and in all the patterns of RCFT in PSS patients compared to the healthy control group (p < .05). It was observed an increased depression frequency and fatigue severity, impairment in health condition, and a decreased quality of life in PSS cases compared to the healthy controls (p < .05). All the depression, fatigue severity, and quality of life tests showed a significant positive correlation with each other (p < .05). A significant negative correlation between Clock Drawing and SF‐36‐BP (p = .031, r = −.382) and SF‐36‐GH (p = .027, r = −.392) was observed. Clock Drawing, PASAT, and AVLT are very useful tests to determine the subclinical and clinical cognitive dysfunction to evaluate attention, information processing speed, executive functions, and short‐term and long‐term verbal memory in PSS patients. Depression and fatigue may not affect the neuropsychological tests performance.
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影响因子：
2.1
作者：
Baturone, R.;Soto, M. J.;Giron-Gonzalez, J. A.
通讯作者：
Giron-Gonzalez, J. A.
影响因子：
4.9
作者：
Haldorsen K;Bjelland I;Bolstad AI;Jonsson R;Brun JG
通讯作者：
Brun JG
影响因子：
27.4
作者：
Hartkamp, A;Geenen, R;Derksen, RHWM
通讯作者：
Derksen, RHWM
影响因子：
5.6
作者：
Busch, RM;Frazier, TW;Kubu, CS
通讯作者：
Kubu, CS
影响因子：
27.4
作者：
Lendrem, Dennis;Mitchell, Sheryl;Ng, Wan-Fai
通讯作者：
Ng, Wan-Fai