Periconceptional folic acid supplementation and child asthma: a Right From the Start follow-up study.
Periconceptional folic acid supplementation and child asthma: a Right From the Start follow-up study.
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DOI：
10.1080/14767058.2022.2122795
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发表时间：
2022-12
影响因子：
1.8
通讯作者：
Carroll, Kecia N.
中科院分区：
文献类型：
--
作者：
Adgent, Margaret A.;Vereen, Shanda;McCullough, Alexis;Jones, Sarah H.;Torstenson, Eric;Edwards, Digna R. Velez;Hartmann, Katherine E.;Carroll, Kecia N.
母亲高叶酸暴露已被研究为儿童哮喘的危险因素，结果不确定。在怀孕前开始补充叶酸可能会在怀孕期间传播高暴露，特别是在有强化食品供应的地区。我们调查了一个美国队列研究中，围怀孕期开始补充叶酸是否与儿童哮喘相关。我们重新联系了以前在前瞻性妊娠队列中登记的母子配对，并包括随访时年龄为4至8岁的儿童（n=540）。使用前三个月的访谈，我们评估了最初的叶酸补充剂（FACS）的使用是否发生在估计怀孕（“围受孕期”）或之后（“前三个月”）。随访问卷被用来确定一个孩子是否曾经有过哮喘诊断（“曾经哮喘”）或哮喘诊断与流行症状或药物使用（“当前哮喘”）。我们使用逻辑回归分析检测了FACS启动和哮喘结局之间的关系，排除早产，并调整了儿童年龄、性别、母亲种族、母亲教育和父母哮喘。大约一半的女性在围受孕期开始使用FACS（49%）。9%的儿童“曾经患有哮喘”，6%的儿童“目前患有哮喘”。与孕早期相比，孕早期开始与既往哮喘（校正比值比[95%置信区间]：1.65 [0.87，3.14]）和当前哮喘（1.87 [0.88，4.01]）的比值升高相关。我们观察到阳性，但不准确估计的关联围认知FACS启动和儿童哮喘。叶酸可以预防出生缺陷，并被推荐。然而，需要更大规模的研究叶酸的剂量和时间，并考虑儿童哮喘。
High maternal folic acid exposure has been studied as a risk factor for child asthma with inconclusive results. Folic acid supplementation that begins before pregnancy may propagate high exposures during pregnancy, particularly in regions with fortified food supplies. We investigated whether folic acid supplementation initiated periconceptionally is associated with childhood asthma in a U.S. cohort. We re-contacted mother-child dyads previously enrolled in a prospective pregnancy cohort and included children age 4 to 8 years at follow-up (n=540). Using first trimester interviews, we assessed whether initial folic acid-containing supplement (FACS) use occurred near/before estimated conception (“periconceptional”) or after (during the “first trimester”). Follow-up questionnaires were used to determine if a child ever had an asthma diagnosis (“ever asthma”) or asthma diagnosis with prevalent symptoms or medication use (“current asthma”). We examined associations between FACS initiation and asthma outcomes using logistic regression, excluding preterm births and adjusting for child age, sex, maternal race, maternal education, and parental asthma. Approximately half of women initiated FACS use periconceptionally (49%). Nine percent of children had “ever asthma” and 6% had “current asthma.” Periconceptional initiation was associated with elevated odds of ever asthma (adjusted Odds Ratio [95% Confidence Interval]: 1.65 [0.87, 3.14]) and current asthma (1.87 [0.88, 4.01]), relative to first trimester initiation. We observed positive, but imprecisely estimated associations between periconceptional FACS initiation and child asthma. Folic acid prevents birth defects and is recommended. However, larger studies of folic acid dosing and timing, with consideration for childhood asthma, are needed.
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影响因子：
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作者：
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通讯作者：
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