A central alarm system that gates multi-sensory innate threat cues to the amygdala.
A central alarm system that gates multi-sensory innate threat cues to the amygdala.
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DOI：
10.1016/j.celrep.2022.111222
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发表时间：
2022-08-16
期刊：
影响因子：
8.8
通讯作者：
Han, Sung
中科院分区：
文献类型：
--
作者：
Kang, Sukjae J.;Liu, Shijia;Ye, Mao;Kim, Dong-Il;Pao, Gerald M.;Copits, Bryan A.;Roberts, Benjamin Z.;Lee, Kuo-Fen;Bruchas, Michael R.;Han, Sung
对威胁的感知对生存至关重要。以前的研究结果表明，平行通路独立地将来自不同感觉方式的先天威胁信号传递到多个大脑区域，如中脑和下丘脑，以立即避免。然而，人们对多感官先天威胁线索是否以及如何从每种感觉方式整合并传达到杏仁核（威胁感知和学习的关键大脑区域）知之甚少。在这里，我们报告说，神经元表达降钙素基因相关肽（CGRP）的小细胞束旁核在丘脑和外外侧臂旁核在脑干多感觉威胁线索从各种感觉方式和继电器负价的外侧和中央杏仁核，分别。CGRP群体及其杏仁核投射都是多感官威胁感知和厌恶记忆形成所必需的。确定统一的先天性威胁途径可能会为开发先天性恐惧相关疾病的治疗候选人提供见解。Kang等人报道，丘脑和脑干中的两个CGRP表达神经元群体被来自各种感觉方式的先天威胁线索激活，并且是其感知所需的。这些CGRP神经元将多感觉威胁线索传递到外侧杏仁核和中央杏仁核，形成两条平行的厌恶记忆形成通路。
Perception of threats is essential for survival. Previous findings suggest that parallel pathways independently relay innate threat signals from different sensory modalities to multiple brain areas, such as the midbrain and hypothalamus, for immediate avoidance. Yet little is known about whether and how multi-sensory innate threat cues are integrated and conveyed from each sensory modality to the amygdala, a critical brain area for threat perception and learning. Here, we report that neurons expressing calcitonin gene-related peptide (CGRP) in the parvocellular subparafascicular nucleus in the thalamus and external lateral parabrachial nucleus in the brainstem respond to multi-sensory threat cues from various sensory modalities and relay negative valence to the lateral and central amygdala, respectively. Both CGRP populations and their amygdala projections are required for multi-sensory threat perception and aversive memory formation. The identification of unified innate threat pathways may provide insights into developing therapeutic candidates for innate fear-related disorders. Kang et al. report that two CGRP-expressing neuronal populations in the thalamus and brainstem are activated by innate threat cues from various sensory modalities and are required for their perception. These CGRP neurons relay multi-sensory threat cues to the lateral and central amygdala, forming two parallel pathways for aversive memory formation.
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