Associations of General and Central Adiposity With Incident Diabetes in Chinese Men and Women.
Associations of General and Central Adiposity With Incident Diabetes in Chinese Men and Women.
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DOI：
10.2337/dc17-1852
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发表时间：
2018-03
期刊：
影响因子：
16.2
通讯作者：
China Kadoorie Biobank (CKB) Collaborative Group
中科院分区：
文献类型：
--
作者：
Bragg F;Tang K;Guo Y;Iona A;Du H;Holmes MV;Bian Z;Kartsonaki C;Chen Y;Yang L;Sun Q;Dong C;Chen J;Collins R;Peto R;Li L;Chen Z;China Kadoorie Biobank (CKB) Collaborative Group
我们评估了中国成年人中全身性肥胖和中心性肥胖以及青年肥胖与糖尿病的关系，并估计了糖尿病的相关人口负担。中国嘉道理生物样本库于2004-08年在中国10个地区招募了512，891名30-79岁的成年人。在9.2年的随访期间，在482，589名基线时没有糖尿病的参与者中记录了13，416例糖尿病病例。考克斯回归分析得出了与全身（如BMI、25岁时的BMI）和中心（如腰围[WC]）肥胖相关的糖尿病事件的校正风险比（HR）。平均（SD）BMI为23.6（3.4）kg/m2，3.8%的患者BMI ≥30 kg/m2。在整个检查范围内（19-32 kg/m2），BMI与糖尿病呈正对数线性关系，男性（1.98，95%CI 1.93-2.04）的每SD调整HR高于女性（1.77，1.73-1.81）（异质性p <0.001）。对于WC，男性的HR/SD为2.13（2.07-2.19），女性为1.91（1.87-1.95）（异质性p <0.001）。相互调整减弱了这些关联，尤其是BMI。25岁时的BMI与糖尿病呈弱正相关（男性1.09 [1.05-1.12];女性1.04 [1.02-1.07]/SD），在校正基线BMI后逆转。在中国，自1980年以来，肥胖增加占糖尿病负担增加的约50%。在相对较瘦的中国成年人中，全身性和中心性肥胖与糖尿病发病风险呈正相关。预计中国肥胖症的持续增加预示着糖尿病发病率的上升。
We assess associations of general and central adiposity in middle-age, and of young adulthood adiposity, with incident diabetes in adult Chinese, and estimate the associated population burden of diabetes. The prospective China Kadoorie Biobank enrolled 512,891 adults aged 30-79 years from 10 localities across China during 2004-08. During 9.2 years follow-up, 13,416 cases of diabetes were recorded among 482,589 participants without diabetes at baseline. Cox regression yielded adjusted hazard ratios (HRs) for incident diabetes associated with measures of general (eg, BMI, BMI at 25y) and central (eg, waist circumference [WC]) adiposity. Mean (SD) BMI was 23.6 (3.4) kg/m2 and 3.8% had BMI ≥30 kg/m2. Throughout the range examined (19-32 kg/m2), BMI showed a positive log-linear relationship with diabetes, with adjusted HRs per SD higher usual BMI greater in men (1.98, 95% CI 1.93-2.04) than women (1.77, 1.73-1.81) (p for heterogeneity <0.001). For WC, HRs per SD were 2.13 (2.07-2.19) in men and 1.91 (1.87-1.95) in women (p for heterogeneity <0.001). Mutual adjustment attenuated these associations, especially those of BMI. BMI at age 25 was weakly positively associated with diabetes (men 1.09 [1.05-1.12]; women 1.04 [1.02-1.07] per SD), which was reversed after adjustment for baseline BMI. In China, increase in adiposity accounted for ~50% of the increase in diabetes burden since 1980. Among relatively lean Chinese adults, higher adiposity—general and central—was strongly positively associated with risk of incident diabetes. The predicted continuing increase in adiposity in China foreshadows escalating rates of diabetes.
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影响因子：
20.3
作者：
Kautzky-Willer A;Harreiter J;Pacini G
通讯作者：
Pacini G
影响因子：
37.8
作者：
Dale CE;Fatemifar G;Palmer TM;White J;Prieto-Merino D;Zabaneh D;Engmann JEL;Shah T;Wong A;Warren HR;McLachlan S;Trompet S;Moldovan M;Morris RW;Sofat R;Kumari M;Hyppönen E;Jefferis BJ;Gaunt TR;Ben-Shlomo Y;Zhou A;Gentry-Maharaj A;Ryan A;UCLEB Consortium; METASTROKE Consortium;Mutsert R;Noordam R;Caulfield MJ;Jukema JW;Worrall BB;Munroe PB;Menon U;Power C;Kuh D;Lawlor DA;Humphries SE;Mook-Kanamori DO;Sattar N;Kivimaki M;Price JF;Davey Smith G;Dudbridge F;Hingorani AD;Holmes MV;Casas JP
通讯作者：
Casas JP
影响因子：
16.2
作者：
de Lauzon-Guillain B;Balkau B;Charles MA;Romieu I;Boutron-Ruault MC;Clavel-Chapelon F
通讯作者：
Clavel-Chapelon F
影响因子：
44.5
作者：
Tian, Ye;Jiang, Chongmin;McNaughton, Lars R.
通讯作者：
McNaughton, Lars R.
影响因子：
5
作者：
COLDITZ, GA;WILLETT, WC;SPEIZER, FE
通讯作者：
SPEIZER, FE