Relationship between Influenza Vaccination Coverage Rate and COVID-19 Outbreak: An Italian Ecological Study.
Relationship between Influenza Vaccination Coverage Rate and COVID-19 Outbreak: An Italian Ecological Study.
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DOI：
10.3390/vaccines8030535
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发表时间：
2020-09-16
期刊：
影响因子：
7.8
通讯作者：
Baldassarre D
中科院分区：
文献类型：
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作者：
Amato M;Werba JP;Frigerio B;Coggi D;Sansaro D;Ravani A;Ferrante P;Veglia F;Tremoli E;Baldassarre D
背景资料：由于缺乏针对2019冠状病毒病（COVID-19）的特异性疫苗或药物，因此需要研究替代临床方法以减少这种大流行性疾病的传播。在这项研究中，我们调查了抗流感疫苗接种是否在最大限度地减少65岁及以上意大利人群中COVID-19的扩散方面发挥作用。研究方法：使用了四种COVID-19结局：严重急性呼吸道综合征冠状病毒2型（SARS-CoV-2）血清阳性率、因COVID-19症状住院、因SARS-CoV-2相关原因入住重症监护室以及因COVID-19导致的死亡。结果如下：在单变量分析中，流感疫苗接种率与所有COVID-19结果呈负相关（Beta范围为-134至-0.61;所有p < 0.01）。在多变量分析中，流感疫苗接种覆盖率与SARS-CoV-2血清阳性率独立相关（β（95% C.I.）：−130（−198，−62）; p = 0.001），因COVID-19症状住院（Beta（95% C.I.）：−4.16（−6.27，−2.05）; p = 0.001），因SARS-CoV-2相关原因入住重症监护室（Beta（95% C.I.）：−0.58（−1.05，−0.12）; p = 0.017），以及COVID-19导致的死亡人数（Beta（95% C.I.）：−3.29（−5.66，−0.93）; p = 0.010）。在多变量分析后，对于所有考虑的结局，未校正分析中观察到的R2从82%增加到159%。结论：在意大利人群中，65岁及以上人群的流感疫苗接种覆盖率与COVID-19的传播减少和临床表现不严重相关。这一发现需要进行特别研究，以调查流感疫苗接种在预防COVID-19传播中的作用。
Background: The lack of specific vaccines or drugs against coronavirus disease 2019 (COVID-19) warrants studies focusing on alternative clinical approaches to reduce the spread of this pandemic disease. In this study, we investigated whether anti-influenza vaccination plays a role in minimizing the diffusion of COVID-19 in the Italian population aged 65 and over. Methods: Four COVID-19 outcomes were used: severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence, hospitalizations for COVID-19 symptoms, admissions to intensive care units for reasons related to SARS-CoV-2, and deaths attributable to COVID-19. Results: At univariate analyses, the influenza vaccination coverage rates correlated negatively with all COVID-19 outcomes (Beta ranging from −134 to −0.61; all p < 0.01). At multivariable analyses, influenza vaccination coverage rates correlated independently with SARS-CoV-2 seroprevalence (Beta (95% C.I.): −130 (−198, −62); p = 0.001), hospitalizations for COVID-19 symptoms (Beta (95% C.I.): −4.16 (−6.27, −2.05); p = 0.001), admission to intensive care units for reasons related to SARS-CoV-2 (Beta (95% C.I.): −0.58 (−1.05, −0.12); p = 0.017), and number of deaths attributable to COVID-19 (Beta (95% C.I.): −3.29 (−5.66, −0.93); p = 0.010). The R2 observed in the unadjusted analysis increased from 82% to 159% for all the considered outcomes after multivariable analyses. Conclusions: In the Italian population, the coverage rate of the influenza vaccination in people aged 65 and over is associated with a reduced spread and a less severe clinical expression of COVID-19. This finding warrants ad hoc studies to investigate the role of influenza vaccination in preventing the spread of COVID-19.
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DOI：
10.1136/heartjnl-2016-309983
发表时间：
2016-12-15
期刊：
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