Functional sympatholysis and sympathetic escape in a theoretical model for blood flow regulation.
Functional sympatholysis and sympathetic escape in a theoretical model for blood flow regulation.
复制标题
DOI：
10.3389/fphys.2014.00192
复制
发表时间：
2014
影响因子：
4
通讯作者：
Secomb TW
中科院分区：
文献类型：
--
作者：
Roy TK;Secomb TW
血管网络中的流量调节的数学模拟用于研究由于交感神经活动（SNA）和血管舒张由于增加的氧气需求之间的相互作用的小动脉血管收缩。使用具有串联的13个血管段的网络，每个段代表不同尺寸范围的小动脉或小静脉。该网络包括五个主动调节小动脉段，其直径随时间变化，受剪切应力、壁张力、代谢调节和SNA的影响。假设代谢信号通过传导响应沿沿着血管壁向上游传播。该模型表现出功能性交感神经松解，其中交感神经血管收缩部分废除代谢需求的增加，和交感神经逃逸，其中SNA eldens一个初始的血管收缩，然后血管舒张。根据实验观察，这些现象在小动脉中比在大动脉中更突出，当SNA被假设为同等地作用于所有大小的小动脉时。结果表明，SNA和进行的代谢信号的小动脉张力的竞争效应的基础上的机制可以解释几个观察到的功能性交感神经溶解的特点，包括大，小动脉的不同反应。
A mathematical simulation of flow regulation in vascular networks is used to investigate the interaction between arteriolar vasoconstriction due to sympathetic nerve activity (SNA) and vasodilation due to increased oxygen demand. A network with 13 vessel segments in series is used, each segment representing a different size range of arterioles or venules. The network includes five actively regulating arteriolar segments with time-dependent diameters influenced by shear stress, wall tension, metabolic regulation, and SNA. Metabolic signals are assumed to be propagated upstream along vessel walls via a conducted response. The model exhibits functional sympatholysis, in which sympathetic vasoconstriction is partially abrogated by increases in metabolic demand, and sympathetic escape, in which SNA elicits an initial vasoconstriction followed by vasodilation. In accordance with experimental observations, these phenomena are more prominent in small arterioles than in larger arterioles when SNA is assumed to act equally on arterioles of all sizes. The results imply that a mechanism based on the competing effects on arteriolar tone of SNA and conducted metabolic signals can account for several observed characteristics of functional sympatholysis, including the different responses of large and small arterioles.
登录
查看更多内容
影响因子：
2.5
作者：
Fry, Brendan C;Roy, Tuhin K;Secomb, Timothy W
通讯作者：
Secomb, Timothy W
DOI：
10.1111/micc.12051
发表时间：
2013-08
期刊：
Microcirculation (New York, N.Y. : 1994)
影响因子：
--
作者：
Golub AS;Pittman RN
通讯作者：
Pittman RN
影响因子：
3.3
作者：
Casey, Darren P.;Walker, Branton G.;Joyner, Michael J.
通讯作者：
Joyner, Michael J.
红细胞：氧传感器和血管张力调节器。
影响因子：
8.4
作者：
Ellsworth, Mary L.;Ellis, Christopher G.;Goldman, Daniel;Stephenson, Alan H.;Dietrich, Hans H.;Sprague, Randy S.
通讯作者：
Sprague, Randy S.
DOI：
10.1152/ajpheart.00491.2001
发表时间：
2002-06-01
影响因子：
4.8
作者：
Cornelissen, AJM;Dankelman, J;Spaan, JAE
通讯作者：
Spaan, JAE