Relations of Psychosocial Factors and Cortisol with Periodontal and Bacterial Parameters: A Prospective Clinical Study in 30 Patients with Periodontitis Before and After Non-Surgical Treatment.
Relations of Psychosocial Factors and Cortisol with Periodontal and Bacterial Parameters: A Prospective Clinical Study in 30 Patients with Periodontitis Before and After Non-Surgical Treatment.
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社会心理因素和皮质醇与牙周和细菌参数的关系：在非手术治疗前后30例牙周炎患者的前瞻性临床研究。
DOI：
10.3390/ijerph17207651
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发表时间：
2020-10-20
影响因子：
--
通讯作者：
Bisson C
中科院分区：
文献类型：
--
作者：
Dubar M;Clerc-Urmès I;Baumann C;Clément C;Alauzet C;Bisson C
(1)背景：多菌物代谢失调引起的牙周炎进展可被影响宿主反应的应激或焦虑等系统或环境因素改变。本研究的目的是评估心理社会因素评分或唾液皮质醇水平与牙周炎患者的临床牙周参数和细菌环境之间的潜在关系。(2)方法：采集30例牙周炎患者的2个病理部位和1个健康部位(洁治和根面平整(SRP)前后)和30例对照患者的1个健康部位的龈下微生物区系。记录常见的临床牙周参数，并采集唾液样本。患者填写压力和焦虑自评问卷。结果：唾液皮质醇水平与牙周袋深度呈正相关(p>；0.05)，与牙周袋深度呈线性正相关(p=0.04)。结果表明，某些心理社会应激源与疾病组(SRP前/后)患者眼袋细菌定植的改变有关，尤其是连翘单胞菌(p=0.02)、牙龈卟啉单胞菌(p=0.03)、核梭杆菌(p=0.049)和直肠弯曲杆菌(p=0.01)。(4)结论：本研究揭示了牙周炎患者的心理社会因素与细菌定植的关系，有待进一步研究。
(1) Background: The progression of periodontitis, induced by polymicrobial dysbiosis, can be modified by systemic or environmental factors such as stress or anxiety affecting host response. The purpose of this study is to evaluate the potential associations between psychosocial factors scores or salivary cortisol levels with clinical periodontal parameters and bacterial environment in patients with periodontitis; (2) Methods: Subgingival microbiota was collected in two pathological and one healthy sites from thirty diseased patients (before/after scaling and root planing (SRP)) and from one healthy site from thirty control patients. Usual clinical periodontal parameters were recorded, and a saliva sample was harvested. Patients completed stress and anxiety self-assessment questionnaires. Cortisol concentrations were determined by ELISA and bacteria were identified by PCR; (3) Results: No correlation between salivary cortisol and the stress-anxiety self-declared was found (p > 0.05), but high concentrations of this molecule were associated positively and linearly with periodontal pocket depth (p = 0.04). It appeared that certain psychosocial stressors are associated with a modulation of the bacterial colonization of pockets of diseased group (before/after SRP), notably concerning Tannerella forsythia (p = 0.02), Porphyromonas gingivalis (p = 0.03), Fusobacterium nucleatum (p = 0.049) and Campylobacter rectus (p = 0.01). (4) Conclusion: This study reveals associations between bacteria colonization and psychosocial parameters in periodontitis that needs to be further investigated.
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影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
影响因子：
3.7
作者：
Hajishengallis G;Lamont RJ
通讯作者：
Lamont RJ
影响因子：
2.3
作者：
Jentsch, H. F. R.;Maerz, Diana;Krueger, Monika
通讯作者：
Krueger, Monika
影响因子：
15.1
作者：
Goehler, LE;Gaykema, RPA;Lyte, M
通讯作者：
Lyte, M
影响因子：
4.8
作者：
Ferreira Mello, Bruna Stefania;Monte, Aline Santos;Macedo, Danielle Silveira
通讯作者：
Macedo, Danielle Silveira