Enhanced Antibacterial Ability of Electrospun PCL Scaffolds Incorporating ZnO Nanowires.
Enhanced Antibacterial Ability of Electrospun PCL Scaffolds Incorporating ZnO Nanowires.
复制标题
具有ZnO纳米线的电纺PCL支架的抗菌能力增强。
DOI：
10.3390/ijms241914420
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发表时间：
2023-09-22
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
植入生物材料支架的感染是一个重大挑战。由于抗生素耐药性的增长和银纳米颗粒的毒性，现有的治疗解决方案，例如抗生素治疗和含银纳米颗粒的支架变得越来越不切实际。我们在这里提出了一个克服这些限制的新概念，即用氧化锌纳米线（ZnO NW）功能化的电纺聚己内酯（PCL）支架。本研究评估了 PCL/ZnO 支架的抗菌能力和生物相容性。通过 SEM 和 EDX 对制备的支架进行了表征，结果表明 ZnO NW 成功掺入并分布在电纺 PCL 支架中。通过将 PCL/ZnO 支架与金黄色葡萄球菌共培养来研究其抗菌性能。与仅使用 PCL 的支架相比，细菌定植减少至 51.3%。通过用 HaCaT 细胞培养 PCL/ZnO 支架来评估其生物相容性。添加 ZnO 纳米线后，PCL 支架的细胞代谢活性没有变化。抗菌和生物相容性特性使PCL/ZnO成为植入支架的良好选择，这项工作为ZnO NWs注入的PCL支架在组织工程的潜在临床应用中奠定了基础。
The infection of implanted biomaterial scaffolds presents a major challenge. Existing therapeutic solutions, such as antibiotic treatment and silver nanoparticle-containing scaffolds are becoming increasingly impractical because of the growth of antibiotic resistance and the toxicity of silver nanoparticles. We present here a novel concept to overcome these limitations, an electrospun polycaprolactone (PCL) scaffold functionalised with zinc oxide nanowires (ZnO NWs). This study assessed the antibacterial capabilities and biocompatibility of PCL/ZnO scaffolds. The fabricated scaffolds were characterised by SEM and EDX, which showed that the ZnO NWs were successfully incorporated and distributed in the electrospun PCL scaffolds. The antibacterial properties were investigated by co-culturing PCL/ZnO scaffolds with Staphylococcus aureus. Bacterial colonisation was reduced to 51.3% compared to a PCL-only scaffold. The biocompatibility of the PCL/ZnO scaffolds was assessed by culturing them with HaCaT cells. The PCL scaffolds exhibited no changes in cell metabolic activity with the addition of the ZnO nanowires. The antibacterial and biocompatibility properties make PCL/ZnO a good choice for implanted scaffolds, and this work lays a foundation for ZnO NWs-infused PCL scaffolds in the potential clinical application of tissue engineering.
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影响因子：
3.4
作者：
Liu M;Liu Y;Zhou L
通讯作者：
Zhou L
影响因子：
18.9
作者：
Ahmed MK;Zayed MA;El-Dek SI;Hady MA;El Sherbiny DH;Uskoković V
通讯作者：
Uskoković V
银纳米颗粒与氧化锌纳米线混合纳米结构通过绿色化学方法作为增强且坚固的抗菌纺织品
影响因子：
3.5
作者：
Li, Zhou;Tang, Haoying;Wang, Zhong Lin
通讯作者：
Wang, Zhong Lin
DOI：
10.1016/j.msec.2017.03.167
发表时间：
2017-09-01
影响因子：
7.9
作者：
Ke, Dongxu;Bose, Susmita
通讯作者：
Bose, Susmita
影响因子：
4.9
作者：
Colon, Gabriel;Ward, Brian C.;Webster, Thomas J.
通讯作者：
Webster, Thomas J.