Anti-tumor activity of triterpenoid-rich extract from bamboo shavings (Caulis bamfusae in Taeniam)
Anti-tumor activity of triterpenoid-rich extract from bamboo shavings (Caulis bamfusae in Taeniam)
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竹屑（Taeniam 中的 Caulis bamfusae）中富含三萜类化合物的提取物的抗肿瘤活性
DOI：
10.5897/ajb09.1657
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发表时间：
2010-09
影响因子：
--
通讯作者：
Zhang, Ying
中科院分区：
文献类型：
--
作者：
Lu, Baiyi;Liu, Lianliang;Zhen, Xiaowei;Wu, Xiaoqin;Zhang, Ying
竹茹是一种中药材，已被卫生部批准为功能性食品原料。研究了竹茹提取物及其主要成分木栓酮的抗肿瘤活性。SRB法和MTT法证实EBS对P388和A549细胞株的生长有明显的抑制作用。与环磷酰胺相比，EBS对荷瘤小鼠S180肉瘤有明显的抑制作用，瘤重呈下降趋势。此外，采用MTT法检测了从EBS中分离出的主要三萜类化合物木栓酮单体的抗肿瘤活性，结果表明木栓酮对A375、L929、HeLa和THP-1四种癌细胞系的增殖均表现出较强的抗肿瘤活性，且与去甲基斑蝥素相比，具有一定的时间-剂量关系。因此，木栓酮是其抗肿瘤活性最重要的活性因子之一，因此木栓酮在功能性食品中具有很大的应用潜力。
Bamboo shavings are a kind of Chinese traditional medicine, which have been certificated as a material of functional food by the Ministry of Health in China. The anti-tumor activities of a triterpenoid-rich extract of bamboo shavings (EBS) and its main component, friedelin were evaluated in the present study. It was proved that EBS could inhibit the growth of P388 and A549 cancer cell lines effectively by SRB and MTT assay. Meanwhile, EBS had notable inhibitory effect on the sarcoma-loaded mice S180 model, which led to a depressed trend of tumor weight, compared to cyclophosphamide. Furthermore, the anti-tumor activity of friedelin monomer, a main triterpenoid separated from EBS, was tested by MTT assay and results showed that friedelin displayed rather strong anti-tumor activities on the proliferation of four cancer lines, A375, L929, Hela and THP-1, with a time-dose relationship compared to de-methylcantharidin, respectively. Therefore, it is suggested that EBS has a great potential to be applied in functional food for its anti-tumor activity, in which friedelin was one of the most important active factors.
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影响因子：
11.2
作者：
T. Ikeda;M. Sporn;T. Honda;G. Gribble;D. Kufe
通讯作者：
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影响因子：
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影响因子：
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影响因子：
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作者：
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通讯作者：
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影响因子：
3.3
作者：
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