Subthalamic Peak Beta Ratio Is Asymmetric in Glucocerebrosidase Mutation Carriers With Parkinson's Disease: A Pilot Study.
Subthalamic Peak Beta Ratio Is Asymmetric in Glucocerebrosidase Mutation Carriers With Parkinson's Disease: A Pilot Study.
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DOI：
10.3389/fneur.2021.723476
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发表时间：
2021
影响因子：
3.4
通讯作者：
Pal GD
中科院分区：
文献类型：
--
作者：
David FJ;Munoz MJ;Shils JL;Pauciulo MW;Hale PT;Nichols WC;Afshari M;Sani S;Verhagen Metman L;Corcos DM;Pal GD
简介：接受丘脑底核深部脑刺激 (STN-DBS) 的个体中，高达 27% 患有遗传性帕金森病 (PD)。与散发性 PD 相比，葡萄糖脑苷脂酶 (GBA) 突变携带者的疾病更具侵袭性、不对称性更小，并且 STN-DBS 的认知结果更差。评估 STN 术中局部场电位提供了评估和比较患有 PD 的 GBA 和非 GBA 突变携带者之间的对称性的机会；因此，提供对基因型和 STN 生理学的深入了解，以及 STN-DBS 的资格和编程。本试点研究的目的是测试患有 PD 的非 GBA 和 GBA 突变携带者左、右 STN 静息态 β 功率的差异。材料和方法：术中记录 4 名 GBA 患者和 5 名非 GBA 停药期间 PD 患者的 STN（左和右）静息态局部场电位。比较 STN 半球和各组之间的峰值 β 功率，以与总 β 功率的比率（峰值 β 比率）表示，同时随年龄、发病年龄和疾病严重程度共同变化。结果：在年龄、发病年龄和疾病严重程度共同变化后，GBA 组左右 STN 的峰值 β 比率存在显着差异 (p < 0.01)，但非 GBA 组则没有显着差异 (p = 0.56)。讨论：与非突变携带者相比，GBA 突变携带者的峰值 β 比率更加不对称，这与通过评定量表测量的临床不对称程度相对应。这一发现表明 GBA 突变携带者具有与散发性 PD 不同的生理特征。
Introduction: Up to 27% of individuals undergoing subthalamic nucleus deep brain stimulation (STN-DBS) have a genetic form of Parkinson's disease (PD). Glucocerebrosidase (GBA) mutation carriers, compared to sporadic PD, present with a more aggressive disease, less asymmetry, and fare worse on cognitive outcomes with STN-DBS. Evaluating STN intra-operative local field potentials provide the opportunity to assess and compare symmetry between GBA and non-GBA mutation carriers with PD; thus, providing insight into genotype and STN physiology, and eligibility for and programming of STN-DBS. The purpose of this pilot study was to test differences in left and right STN resting state beta power in non-GBA and GBA mutation carriers with PD. Materials and Methods: STN (left and right) resting state local field potentials were recorded intraoperatively from 4 GBA and 5 non-GBA patients with PD while off medication. Peak beta power expressed as a ratio to total beta power (peak beta ratio) was compared between STN hemispheres and groups while co-varying for age, age of disease onset, and disease severity. Results: Peak beta ratio was significantly different between the left and the right STN for the GBA group (p < 0.01) but not the non-GBA group (p = 0.56) after co-varying for age, age of disease onset, and disease severity. Discussion: Peak beta ratio in GBA mutation carriers was more asymmetric compared with non-mutation carriers and this corresponded with the degree of clinical asymmetry as measured by rating scales. This finding suggests that GBA mutation carriers have a physiologic signature that is distinct from that found in sporadic PD.
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DOI：
10.1016/j.nicl.2017.02.010
发表时间：
2017
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Heinrichs-Graham E;Santamaria PM;Gendelman HE;Wilson TW
通讯作者：
Wilson TW
影响因子：
3.4
作者：
Kühn, AA;Kupsch, A;Brown, P
通讯作者：
Brown, P
影响因子：
11
作者：
HUGHES, AJ;DANIEL, SE;LEES, AJ
通讯作者：
LEES, AJ
影响因子：
5.3
作者：
Kuehn, Andrea A.;Tsui, Alexander;Brown, Peter
通讯作者：
Brown, Peter
影响因子：
1.7
作者：
Bus, Sander;Pal, Gian;Metman, Leo Verhagen
通讯作者：
Metman, Leo Verhagen