The influence of size, shape and vessel geometry on nanoparticle distribution.
The influence of size, shape and vessel geometry on nanoparticle distribution.
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DOI：
10.1007/s10404-012-1024-5
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发表时间：
2013-01-01
影响因子：
2.8
通讯作者：
Liu, Yaling
中科院分区：
文献类型：
--
作者：
Tan, Jifu;Shah, Samar;Thomas, Antony;Ou-Yang, H. Daniel;Liu, Yaling
纳米粒子（NPs）正在成为有前途的载体平台，用于靶向药物递送和成像探针。为了评估递送效率，重要的是预测NP在血管内的分布。NP的大小、形状和血管几何形状被认为影响其在循环中的生物分布。然而，尺寸对纳米颗粒分布的影响已被广泛研究，形状和血管几何形状的影响知之甚少。本文描述了一个计算模型的NP输运和分布在一个模拟的分支血管使用相结合的NP布朗动力学和连续介质流体力学方法。模拟结果表明，较小尺寸和棒状的纳米颗粒由于较小的阻力和较大的接触面积而具有较高的结合能力。棒状纳米粒子的结合动力学被发现是依赖于他们的初始接触点和方向的墙壁。与分支血管的直段相比，在分叉区域观察到更高浓度的NP。此外，它被发现，Péclet数起着重要的作用，在决定的分数纳米粒子沉积在分支区域和直线段。模拟结果还表明，NP结合随着剪切速率的增加而减少。动态NP再分布从低到高剪切速率观察到由于在分支通道上的不均匀的剪切应力分布。本研究为NP在复杂血管网络中的分布提供了有价值的信息。
Nanoparticles (NPs) are emerging as promising carrier platforms for targeted drug delivery and imaging probes. To evaluate the delivery efficiency, it is important to predict the distribution of NPs within blood vessels. NP size, shape and vessel geometry are believed to influence its biodistribution in circulation. Whereas, the effect of size on nanoparticle distribution has been extensively studied, little is known about the shape and vessel geometry effect. This paper describes a computational model for NP transport and distribution in a mimetic branched blood vessel using combined NP Brownian dynamics and continuum fluid mechanics approaches. The simulation results indicate that NPs with smaller size and rod shape have higher binding capabilities as a result of smaller drag force and larger contact area. The binding dynamics of rod-shaped NPs is found to be dependent on their initial contact points and orientations to the wall. Higher concentration of NPs is observed in the bifurcation area compared to the straight section of the branched vessel. Moreover, it is found that Péclet number plays an important role in determining the fraction of NPs deposited in the branched region and the straight section. Simulation results also indicate that NP binding decreases with increased shear rate. Dynamic NP re-distribution from low to high shear rates is observed due to the non-uniform shear stress distribution over the branched channel. This study would provide valuable information for NP distribution in a complex vascular network.
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影响因子：
3.8
作者：
Barber, Jared O.;Alberding, Jonathan P.;Restrepo, Juan M.;Secomb, Timothy W.
通讯作者：
Secomb, Timothy W.
影响因子：
4.2
作者：
Liu Y;Tan J;Thomas A;Ou-Yang D;Muzykantov VR
通讯作者：
Muzykantov VR
影响因子：
--
作者：
Lee, Tae-Rin;Chang, Yoon-Suk;Kim, Young-Jin
通讯作者：
Kim, Young-Jin
DOI：
10.1073/pnas.1006611107
发表时间：
2010-09-21
影响因子：
11.1
作者：
Liu, Jin;Weller, Gregory E. R.;Radhakrishnan, Ravi
通讯作者：
Radhakrishnan, Ravi
影响因子：
5.2
作者：
LI, A;AHMADI, G
通讯作者：
AHMADI, G