Increased activity imbalance in fronto-subcortical circuits in adolescents with major depression.
Increased activity imbalance in fronto-subcortical circuits in adolescents with major depression.
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重度抑郁症青少年额叶皮层下回路活动失衡加剧
DOI：
10.1371/journal.pone.0025159
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Liu Y
中科院分区：
文献类型：
--
作者：
Jiao Q;Ding J;Lu G;Su L;Zhang Z;Wang Z;Zhong Y;Li K;Ding M;Liu Y
背景：由于不同区域的成熟轨迹，青少年的额叶和皮层下区域存在功能差异。目前尚不清楚这种功能差异是如何改变的，以及从皮层下到额叶系统的影响是否在药物治疗中起主要作用naïve青少年重度抑郁症（MDD）。研究方法/主要发现纳入18名重度抑郁症青少年和18名健康青少年。抑郁和焦虑的严重程度分别通过短期情绪和感觉问卷（SMFQ）和儿童焦虑相关情绪障碍筛查（SCARED）进行评估。通过静息状态功能MRI信号的低频波动幅度（ALFF）测量功能差异。对ALFF值与SMFQ、SCARED评分进行相关性分析。在HC和MDD青少年中，ALFF测量的静息脑活动水平在额叶皮层高于主要涉及边缘纹状体区域的皮层下系统。与对照组相比，MDD青少年额叶和皮层下系统间ALFF值的差异有所增加。结论/意义本研究发现，在MDD青少年中，静息状态大脑活动在额叶认知控制系统和（准）边缘纹状体情绪处理系统之间的失衡增加。这一发现可能为青少年重度抑郁症的神经关联提供了新的见解。
Background A functional discrepancy exists in adolescents between frontal and subcortical regions due to differential regional maturational trajectories. It remains unknown how this functional discrepancy alters and whether the influence from the subcortical to the frontal system plays a primacy role in medication naïve adolescent with major depressive disorder (MDD). Methodology/Principal Findings Eighteen MDD and 18 healthy adolescents were enrolled. Depression and anxiety severity was assessed by the Short Mood and Feeling Questionnaire (SMFQ) and Screen for Child Anxiety Related Emotional Disorders (SCARED) respectively. The functional discrepancy was measured by the amplitude of low-frequency fluctuations (ALFF) of resting-state functional MRI signal. Correlation analysis was carried out between ALFF values and SMFQ and SCARED scores. Resting brain activity levels measured by ALFF was higher in the frontal cortex than that in the subcortical system involving mainly (para) limbic-striatal regions in both HC and MDD adolescents. The difference of ALFF values between frontal and subcortical systems was increased in MDD adolescents as compared with the controls. Conclusions/Significance The present study identified an increased imbalance of resting-state brain activity between the frontal cognitive control system and the (para) limbic-striatal emotional processing system in MDD adolescents. The findings may provide insights into the neural correlates of adolescent MDD.
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DOI：
10.1073/pnas.0402680101
发表时间：
2004-05-25
影响因子：
11.1
作者：
Gogtay, N;Giedd, JN;Thompson, PM
通讯作者：
Thompson, PM
影响因子：
5.7
作者：
Esterman, Michael;Tamber-Rosenau, Benjamin J.;Chiu, Yu-Chin;Yantis, Steven
通讯作者：
Yantis, Steven
DOI：
10.1097/00004583-199704000-00018
发表时间：
1997-04-01
影响因子：
13.3
作者：
Birmaher, B;Khetarpal, S;Neer, SM
通讯作者：
Neer, SM
影响因子：
10.6
作者：
Chen, Chi-Hua;Ridler, Khanum;Bullmore, Edward T.
通讯作者：
Bullmore, Edward T.
影响因子：
5.6
作者：
Drevets, WC;Bogers, W;Raichle, ME
通讯作者：
Raichle, ME