Airflow dynamics in obese minipigs with obstructive sleep apnea.
Airflow dynamics in obese minipigs with obstructive sleep apnea.
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DOI：
10.1016/j.heliyon.2020.e05700
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发表时间：
2021-01
期刊：
影响因子：
4
通讯作者：
Fong H
中科院分区：
文献类型：
--
作者：
Liu ZJ;Do T;Fong H
阻塞性睡眠呼吸暂停 (OSA) 与咽部气道的解剖学限制有关，但 OSA 中气流动力学的机制尚不清楚。本研究利用计算流动动力学 (CFD) 建立了咽部的 3D 模型，并检验了以下假设：OSA/肥胖小型猪的咽部限制增加会导致更高的阻力，进而产生湍流，导致咽部气道通畅暂时阻塞。 5 头 9-11 个月大的尤卡坦小型猪中，3 头为非肥胖（BMI<35），2 头为肥胖（BMI>51）。使用 BioRadio 系统进行自然睡眠监测后，给猪注射镇静剂以收集 MRI 图像和气流参数。对 MRI 图像进行处理以创建咽部的 3D 配置。对这些 3D 配置进行网格划分以创建 CFD 的有限元模型 (FEM)。将获得的气流参数输入到配置中以识别湍流气流及其位置。两只肥胖小型猪在睡眠期间均发现严重打鼾和多次 >5 秒的呼吸不足/呼吸暂停发作 (AHI = 32-35)。与非肥胖/非 OSA 对照相比，肥胖/OSA 小型猪的呼吸潮气量和吸气气流速度要低得多。有限元模拟发现，两种模型的咽部均不存在湍流。然而，在肥胖/OSA 小型猪模型中，鼻咽最狭窄部分的气流速度增加了 25%。尽管咽部气道较窄且气流速度较高，但有限元模拟表明，肥胖/OSA小型猪中并未产生湍流。阻塞性睡眠呼吸暂停；计算气流动力学；咽部气道；呼吸;肥胖;猪；健康科学；呼吸系统；生理;解剖学;眼耳鼻喉
Obstructive sleep apnea (OSA) is associated with anatomical restrictions of pharyngeal airway, but the mechanism of airflow dynamics in OSA is largely unknown. This study utilized computational flow dynamics (CFD) to build a 3D model of the pharynx and to test the hypothesis that an increased restriction in the pharynx in OSA/obese minipigs leads to higher resistance, which in turn creates turbulence to induce temporary blockage of pharyngeal airway patency. Of five 9-11-months-old Yucatan minipigs, 3 were non-obese (BMI<35) and two obese (BMI>51). After natural sleep monitoring using BioRadio system, pigs were sedated to collect MRI images and airflow parameters. The MRI images were processed to create 3D configurations of pharynx. These 3D configurations were meshed to create finite element models (FEM) of CFD. The obtained airflow parameters were input into the configurations to identify turbulent airflow and its location. Heavy snoring and multiple >5s hypopnea/apnea episodes (AHI = 32–35) were identified in both obese minipigs during sleep. Compared to the non-obese/non-OSA controls, obese/OSA minipigs showed much lower respiratory tidal volumes and inspiratory airflow speed. FEM simulation found that turbulence was not present in the pharynx in either model. However, a 25% increase of airflow velocity was observed at the narrowest part of the nasal pharynx in the obese/OSA minipig model. Despite the narrower pharyngeal airway and the higher velocity of airflow, FEM simulation indicated that turbulence was not produced in the obese/OSA minipigs. Obstructive sleep apnea; Computational airflow dynamics; Pharyngeal airway; respiration; Obesity; Pigs; Health Sciences; Respiratory System; Physiology; Anatomy; Eye-Ear-Nose-Throat
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DOI：
10.1002/hed.21841
发表时间：
2011-10
影响因子：
2.9
作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
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影响因子：
2.6
作者：
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通讯作者：
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影响因子：
2.2
作者：
Jeong, Soo-Jin;Kim, Woo-Seung;Sung, Sang-Jin
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