Prenatal exposure to tobacco smoke leads to increased mitochondrial DNA content in umbilical cord serum associated to reduced gestational age.
Prenatal exposure to tobacco smoke leads to increased mitochondrial DNA content in umbilical cord serum associated to reduced gestational age.
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DOI：
10.1080/09603123.2016.1268677
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发表时间：
2017-03
影响因子：
3.2
通讯作者：
Guerrero-Preston R
中科院分区：
文献类型：
--
作者：
Pirini F;Goldman LR;Soudry E;Halden RU;Witter F;Sidransky D;Guerrero-Preston R
We investigated if prenatal exposures to tobacco smoke leads to changes in mitochondrial DNA content (mtDNA) in cord serum and adversely affect newborns health. Umbilical cord serum cotinine levels were used to determine in-utero exposure to smoking. Cord serum mtDNA was measured by quantitative PCR analysis of the genes coding for cytochrome c oxidase1 (MT-CO1) and cytochrome c oxidase2 (MT-CO2). Log transformed levels of mtDNA coding for MT-CO1 and MT-CO2 were significantly higher among infants of active smokers with higher serum level of cotinine (p<0.05) and inversely associated with gestational age (p=0.08; p=0.02). Structural equation modeling results confirmed a positive association between cotinine and MT-CO1 and2 (p<0.01) and inverse associations with gestational age (p=0.02) and IGF-1 (p<0.01). We identified a dose-dependent increase in the level of MT-CO1 and MT-CO2 associated to increases cord serum cotinine and decreased gestational age.
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影响因子：
10.4
作者：
Herbstman JB;Sjödin A;Apelberg BJ;Witter FR;Halden RU;Patterson DG;Panny SR;Needham LL;Goldman LR
通讯作者：
Goldman LR
影响因子：
7.4
作者：
Fukagawa, NK;Li, MY;Absher, PM
通讯作者：
Absher, PM
影响因子：
9.8
作者：
Colleoni, Francesca;Lattuada, Debora;Cetin, Irene
通讯作者：
Cetin, Irene
影响因子：
5.5
作者：
Castles, A;Adams, EK;Boulton, ML
通讯作者：
Boulton, ML
DOI：
10.1016/j.ijheh.2012.12.014
发表时间：
2013-07
影响因子：
6
作者：
Jedrychowski, Wieslaw A.;Perera, Frederica P.;Spengler, John D.;Mroz, Elzbieta;Stigter, Laura;Flak, Elzbieta;Majewska, Renata;Klimaszewska-Rembiasz, Maria;Jacek, Ryszard
通讯作者：
Jacek, Ryszard