The diagnosis of fetal alcohol syndrome.
The diagnosis of fetal alcohol syndrome.
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胎儿酒精综合症的诊断。
DOI：
10.3238/arztebl.2013.0703
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发表时间：
2013
影响因子：
7.7
通讯作者：
F. Heinen
中科院分区：
文献类型：
--
作者：
M. Landgraf;M. Nothacker;I. Kopp;F. Heinen
背景
胎儿酒精综合征（FAS）的估计患病率为每1000例活产8例。FAS对受影响的儿童及其家庭造成严重的终身后果。各种各样的专业人士处理FAS患者，包括儿科医生，全科医生，神经科医生，妇科医生，精神科医生和心理治疗师。早期诊断很重要，这样受影响的儿童就可以在保护性环境中得到他们所需要的支持。
方法
一个多学科指南小组在评估了现有的科学证据后，发布了FAS诊断的建议。该信息来源于通过系统检索PubMed和科克伦图书馆检索到的相关文献（2001-2011年）、沿着美国和加拿大指南以及通过手动检索检索到的其他文献。
结果
在检索到的1383篇出版物中，分析了178篇出版物所包含的证据。得出的结论是，FAS的完全发展的临床综合征应根据以下标准进行诊断：患者必须至少有一种生长异常，例如，身材矮小，以及所有三个特征性的面部异常-睑裂长度短，上唇薄，人中光滑。他们还必须有至少一个诊断的中枢神经系统的结构或功能异常，例如，小头畸形或执行功能受损。确诊胎儿宫内接触酒精并不是诊断的必要条件。
结论
现在已经建立了诊断完全发展的FAS综合征的实用、循证标准。需要进行更多的研究，以便对所有胎儿酒精谱系障碍进行统一的循证诊断评估，并优化受其影响的儿童的支持措施。
BACKGROUND
The estimated prevalence of fetal alcohol syndrome (FAS) is 8 for every 1000 live births. FAS has serious, lifelong consequences for the affected children and their families. A variety of professionals deal with persons who have FAS, including pediatricians, general practitioners, neurologists, gynecologists, psychiatrists, and psychotherapists. Early diagnosis is important so that the affected children can receive the support they need in a protective environment.
METHODS
A multidisciplinary guideline group has issued recommendations for the diagnosis of FAS after assessment of the available scientific evidence. This information was derived from pertinent literature (2001-2011) retrieved by a systematic search in PubMed and the Cochrane Library, along with the US-American and Canadian guidelines and additional literature retrieved by a manual search.
RESULTS
Of the 1383 publications retrieved by the searches, 178 were analyzed for the evidence they contained. It was concluded that the fully-developed clinical syndrome of FAS should be diagnosed on the basis of the following criteria: Patients must have at least one growth abnormality, e.g., short stature, as well as all three characteristic facial abnormalities-short palpebral fissure length, a thin upper lip, and a smooth philtrum. They must also have at least one diagnosed structural or functional abnormality of the central nervous system, e.g., microcephaly or impaired executive function. Confirmation of intrauterine exposure to alcohol is not obligatory for the diagnosis.
CONCLUSION
Practical, evidence-based criteria have now been established for the diagnosis of the fully-developed FAS syndrome. More research is needed in order to enable uniform, evidence-based diagnostic assessment of all fetal alcohol spectrum disorders and optimize supportive measures for the children affected by them.
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加拿大睑裂长度生长图表反映了非常适合两个学校和 FASD 诊所的美国人群。
DOI：
--
发表时间：
2011
期刊：
Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharamcologie clinique
影响因子：
--
作者：
Astley,SusanJ
通讯作者：
Astley,SusanJ
影响因子：
2.3
作者：
Burd, Larry;Klug, Marilyn G.;Martsolf, John T.
通讯作者：
Martsolf, John T.
DOI：
10.1111/j.1530-0277.2002.tb02459.x
发表时间：
2002-10
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
N. Day;S. Leech;G. Richardson;M. Cornelius;N. Robles;Cynthia A. Larkby
通讯作者：
N. Day;S. Leech;G. Richardson;M. Cornelius;N. Robles;Cynthia A. Larkby
产前大量饮酒的个体皮质厚度异常和大脑行为相关模式。
DOI：
10.1093/cercor/bhm039
发表时间：
2008
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Sowell,ElizabethR;Mattson,SarahN;Kan,Eric;Thompson,PaulM;Riley,EdwardP;Toga,ArthurW
通讯作者：
Toga,ArthurW
影响因子：
3.7
作者：
Yaling Yang;Florence F. Roussotte;E. Kan;K. Sulik;S. Mattson;E. Riley;K. Jones;C. Adnams;P. May-P.-M
通讯作者：
Yaling Yang;Florence F. Roussotte;E. Kan;K. Sulik;S. Mattson;E. Riley;K. Jones;C. Adnams;P. May-P.-M