Neurod6 expression defines new retinal amacrine cell subtypes and regulates their fate.
Neurod6 expression defines new retinal amacrine cell subtypes and regulates their fate.
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DOI：
10.1038/nn.2859
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发表时间：
2011-07-10
影响因子：
25
通讯作者：
Sanes, Joshua R.
中科院分区：
文献类型：
--
作者：
Kay, Jeremy N.;Voinescu, P. Emanuela;Chu, Monica W.;Sanes, Joshua R.
中枢神经系统的大多数区域都包含许多在电路功能中扮演专业角色的抑制性中间神经元的亚型。在哺乳动物的视网膜中，称为无链氨酸细胞（AC）的抑制性中间神经元的30个亚型通常分为两组：宽/中场Gabaergic和窄场甘氨酸能，它们分别介导了内丛状层内的侧向相互作用和垂直相互作用。我们使用表达分析和小鼠转基因线来识别和表征两个密切相关的窄场AC亚型。令人惊讶的是，两者在产后出现，既不是甘油能，也不是Gabaergic（NGNG）。这些亚型NeuroD6和SATB2选择性地表达了两个转录因子，调节了它们之间的有丝分裂细胞命运。 SATB2诱导NeuroD6，它持续在NGNG AC中并促进其命运，但在相关的甘氨酸AC亚型中被下调。我们的结果支持这样一种观点，即祖细胞中的细胞命运决定及其后代行为共同使AC多样化。
Most regions of the central nervous system contain numerous subtypes of inhibitory interneurons that play specialized roles in circuit function. In mammalian retina, the ~30 subtypes of inhibitory interneurons called amacrine cells (ACs) are generally divided into two groups: wide/medium-field GABAergic and narrow-field glycinergic, which mediate lateral and vertical interactions, respectively, within the inner plexiform layer. We used expression profiling and mouse transgenic lines to identify and characterize two closely-related narrow-field AC subtypes. Both arise postnatally and one, surprisingly, is neither glycinergic nor GABAergic (nGnG). Two transcription factors selectively expressed by these subtypes, Neurod6 and Satb2, regulate a postmitotic cell fate choice between them. Satb2 induces Neurod6, which persists in nGnG ACs and promotes their fate, but is down-regulated in the related glycinergic AC subtype. Our results support the view that cell fate decisions made in progenitors and their progeny act together to diversify ACs.
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影响因子：
2.5
作者：
Hsueh, Hain-Ann;Molnar, Alyosha;Werblin, Frank S.
通讯作者：
Werblin, Frank S.
DOI：
10.1002/cne.22200
发表时间：
2009-12-10
期刊：
The Journal of comparative neurology
影响因子：
--
作者：
Voinescu PE;Kay JN;Sanes JR
通讯作者：
Sanes JR
影响因子：
3.6
作者：
Jusuf PR;Harris WA
通讯作者：
Harris WA
影响因子：
16.2
作者：
Alcamo, Elizabeth A.;Chirivella, Laura;McConnell, Susan K.
通讯作者：
McConnell, Susan K.
影响因子：
2.5
作者：
Elshatory, Yasser;Deng, Min;Gan, Lin
通讯作者：
Gan, Lin