A shared neural ensemble links distinct contextual memories encoded close in time.
A shared neural ensemble links distinct contextual memories encoded close in time.
复制标题
DOI：
10.1038/nature17955
复制
发表时间：
2016-06-02
期刊：
影响因子：
64.8
通讯作者：
Silva, Alcino J.
中科院分区：
文献类型：
--
作者：
Cai, Denise J.;Aharoni, Daniel;Shuman, Tristan;Shobe, Justin;Biane, Jeremy;Song, Weilin;Wei, Brandon;Veshkini, Michael;La-Vu, Mimi;Lou, Jerry;Flores, Sergio E.;Kim, Isaac;Sano, Yoshitake;Zhou, Miou;Baumgaertel, Karsten;Lavi, Ayal;Kamata, Masakazu;Tuszynski, Mark;Mayford, Mark;Golshani, Peyman;Silva, Alcino J.
最近的研究提出了一种假设，即共享的神经集合可能将在时间上接近编码的不同记忆联系起来。根据记忆分配假说，学习触发了神经元兴奋性的暂时增加，使随后记忆的表征偏向于编码第一记忆的神经元集合，这样一个记忆的回忆增加了回忆另一个记忆的可能性。因此，我们报告说，在一天内获得的两个不同的情况下激活的海马CA1区合奏之间的重叠是高于当他们分开一个星期。多个收敛的研究结果表明，这种重叠的神经元合奏链接两个上下文记忆。首先，当恐惧和一种情境在一天之内而不是一周之内获得时，恐惧就会被转移到一个中性的情境中。第二，第一个记忆在一天之内加强了第二个记忆，但在一周之内不会。年长的老鼠，已知具有较低的CA1兴奋性，没有显示出合奏之间的重叠，恐惧在上下文之间的转移，或第二记忆的加强。最后，在老年动物中，在两个不同的背景暴露期间，增加细胞兴奋性和激活CA1神经元的共同集合挽救了连接记忆的缺陷。总之，这些发现表明，在时间上接近编码的上下文记忆是通过将存储定向到重叠的集合中来连接的。随着年龄的增长，这些过程的改变可能会影响记忆的时间结构，从而影响相关信息的有效回忆。
Recent studies suggest the hypothesis that a shared neural ensemble may link distinct memories encoded close in time. According to the memory allocation hypothesis, learning triggers a temporary increase in neuronal excitability that biases the representation of a subsequent memory to the neuronal ensemble encoding the first memory, such that recall of one memory increases the likelihood of recalling the other memory. Accordingly, we report that the overlap between the hippocampal CA1 ensembles activated by two distinct contexts acquired within a day is higher than when they are separated by a week. Multiple convergent findings indicate that this overlap of neuronal ensembles links two contextual memories. First, fear paired with one context is transferred to a neutral context when the two are acquired within a day but not across a week. Second, the first memory strengthens the second memory within a day but not across a week. Older mice, known to have lower CA1 excitability, do not show the overlap between ensembles, the transfer of fear between contexts, or the strengthening of the second memory. Finally, in aged animals, increasing cellular excitability and activating a common ensemble of CA1 neurons during two distinct context exposures rescued the deficit in linking memories. Taken together, these findings demonstrate that contextual memories encoded close in time are linked by directing storage into overlapping ensembles. Alteration of these processes by aging could affect the temporal structure of memories, thus impairing efficient recall of related information.
登录
查看更多内容
DOI：
10.1073/pnas.1214107109
发表时间：
2012-11-20
影响因子：
11.1
作者：
Mankin, Emily A.;Sparks, Fraser T.;Leutgeb, Jill K.
通讯作者：
Leutgeb, Jill K.
影响因子：
16.2
作者：
McKenzie S;Frank AJ;Kinsky NR;Porter B;Rivière PD;Eichenbaum H
通讯作者：
Eichenbaum H
影响因子：
3.5
作者：
Frankland, PW;Josselyn, A;Silva, AJ
通讯作者：
Silva, AJ
DOI：
10.1126/science.1214985
发表时间：
2012-03-23
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Garner AR;Rowland DC;Hwang SY;Baumgaertel K;Roth BL;Kentros C;Mayford M
通讯作者：
Mayford M
影响因子：
5.4
作者：
Sederberg, Per B.;Howard, Marc W.;Kahana, Michael J.
通讯作者：
Kahana, Michael J.