Hippocampal representation of related and opposing memories develop within distinct, hierarchically organized neural schemas.

Hippocampal representation of related and opposing memories develop within distinct, hierarchically organized neural schemas.
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DOI:
10.1016/j.neuron.2014.05.019
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发表时间:
2014-07-02
期刊:
影响因子:
16.2
通讯作者:
Eichenbaum H
Eichenbaum H
中科院分区:
医学1区
文献类型:
--
作者:
McKenzie S;Frank AJ;Kinsky NR;Porter B;Rivière PD;Eichenbaum H

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Recent evidence suggests that the hippocampus may integrate overlapping memories into relational representations, or schemas, that link indirectly related events and support flexible memory expression. Here we explored the nature of hippocampal neural population representations for multiple features of events and the locations and contexts in which they occurred. Hippocampal networks developed hierarchical organizations of associated elements of related but separately acquired memories within a context, and distinct organizations for memories where the contexts differentiated object-reward associations. These findings reveal neural mechanisms for the development and organization of relational representations.
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