Diabetes Mellitus and Obesity as Risk Factors for Pancreatic Cancer.
Diabetes Mellitus and Obesity as Risk Factors for Pancreatic Cancer.
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DOI：
10.1016/j.jand.2017.07.005
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发表时间：
2018-04
影响因子：
4.8
通讯作者：
Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer
中科院分区：
文献类型：
--
作者：
Eibl G;Cruz-Monserrate Z;Korc M;Petrov MS;Goodarzi MO;Fisher WE;Habtezion A;Lugea A;Pandol SJ;Hart PA;Andersen DK;Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer
胰腺导管腺癌（PDAC）仍然是最致命的癌症类型之一。全世界一般人群的发病率和死亡率估计为每100，000人年8例，每100，000人年7例死亡，美国的发病率和死亡率明显高于世界其他地区。2017年，美国（US）的这种疾病的发病率超过50，000例新病例。事实上，预计PDAC导致的总死亡人数将大幅增加，在2030年之前成为癌症相关死亡的第二大原因。考虑到迄今为止未能有效治疗现有的PDAC，应加大努力预防这种疾病。更好地了解导致PDAC发展的风险因素对于确定和制定预防策略至关重要。大型流行病学和队列研究已经确定了PDAC发生的风险因素，包括肥胖和2型糖尿病（T2 DM）。本文综述了肥胖和T2DM作为PDAC发展和进展的危险因素的现有知识，它们的相互作用和潜在机制，与饮食的关系，以及概述了解决这种致命疾病的研究差距和机会。
Pancreatic ductal adenocarcinoma (PDAC) is still one of the deadliest types of cancer. The worldwide estimates of its incidence and mortality in the general population are 8 cases per 100,000 person-years and 7 deaths per 100,000 person-years, and they are significantly higher in the United States than the rest of the world. The incidence of this disease in the United States (US) is over 50,000 new cases in 2017. Indeed, total deaths due to PDAC are projected to increase dramatically to become the second leading cause of cancer-related deaths before 2030. Considering the failure to date to efficiently treat existing PDAC, increased effort should be undertaken to prevent this disease. A better understanding of the risk factors leading to PDAC development is of utmost importance to identify and formulate preventive strategies. Large epidemiological and cohort studies have identified risk factors for the development of PDAC, including obesity and type-2 diabetes mellitus (T2DM). This review highlights the current knowledge of obesity and T2DM as risk factors for PDAC development and progression, their interplay and underlying mechanisms, the relation to diet, as well as outlines research gaps and opportunities to address this deadly disease.
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影响因子：
29.4
作者：
Apte MV;Wilson JS;Lugea A;Pandol SJ
通讯作者：
Pandol SJ
影响因子：
8.2
作者：
Butler, A. E.;Galasso, R.;Matveyenko, A.;Rizza, R. A.;Dry, S.;Butler, P. C.
通讯作者：
Butler, P. C.
影响因子：
10.3
作者：
Bao, Ying;Giovannucci, Edward L.;Wolpin, Brian M.
通讯作者：
Wolpin, Brian M.
胰腺癌的危险因素：潜在的机制和潜在靶标。
影响因子：
4
作者：
Edderkaoui M;Eibl G
通讯作者：
Eibl G
DOI：
10.1093/ajcn/88.2.431
发表时间：
2008-08
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Bao Y;Stolzenberg-Solomon R;Jiao L;Silverman DT;Subar AF;Park Y;Leitzmann MF;Hollenbeck A;Schatzkin A;Michaud DS
通讯作者：
Michaud DS