Changes in Choroidal Structures in Eyes with Chronic Central Serous Chorioretinopathy after Half-Dose Photodynamic Therapy.
Changes in Choroidal Structures in Eyes with Chronic Central Serous Chorioretinopathy after Half-Dose Photodynamic Therapy.
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DOI：
10.1371/journal.pone.0163104
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Sakamoto T
中科院分区：
文献类型：
--
作者：
Kinoshita T;Mitamura Y;Mori T;Akaiwa K;Semba K;Egawa M;Mori J;Sonoda S;Sakamoto T
目的探讨半剂量光动力治疗（hPDT）对慢性中枢性浆液性脉络膜视网膜病变（CSC）后脉络膜结构的改变。这是一项回顾性介入研究，29名慢性CSC合并浆液性视网膜脱离（SRD）患者的29只眼睛接受了hPDT治疗，随访时间≥3个月。将中央凹下脉络膜增强深度成像光学相干层析成像（edii - oct）图像转换为二值图像。在基线、hPDT后1、3和12个月测定中央脉络膜厚度（CCT）、横截中央凹下脉络膜面积、内、外和整个脉络膜的低反射和高反射区域。在hPDT术后3个月，26只（89.7%）眼的SRDs消失。3个月时，平均CCT （P = 0.001）、总脉络膜面积（P = 0.001）和全脉络膜低反射面积（P = 0.003）较基线显著降低。全脉络膜高反射面积在研究期间无明显变化（P = 0.083）。3个月时，内脉膜高反射区明显减少，低反射区无明显减少（P = 0.001, P = 1.000）。3个月时，外脉络膜低反射区明显减少，高反射区无明显减少（P = 0.001, P = 1.000）。hPDT治疗慢性CSC后，内脉络膜高反射区和外脉络膜低反射区明显减少。由于高反射区和低反射区分别对应于脉络膜间质和血管，hPDT后CCT和中央凹下脉络膜面积的减少可能是由于内脉络膜间质渗出变化的减少和外脉络膜血管扩张的减少。
To determine the structural changes in the choroid after half-dose photodynamic therapy (hPDT) in eyes with chronic central serous chorioretinopathy (CSC). This was a retrospective interventional study of 29 eyes of 29 patients who underwent hPDT for chronic CSC with serous retinal detachment (SRD) and were followed for ≥3 months. Enhanced depth imaging optical coherence tomographic (EDI-OCT) images of the subfoveal choroid were converted to binary images. The central choroidal thickness (CCT), the cross sectional subfoveal choroidal area, the hyporeflective and hyperreflective areas of the inner, outer, and whole choroid were determined at the baseline, and at 1, 3, and 12 months after the hPDT. The SRDs were resolved in 26 (89.7%) eyes at 3 months after the hPDT. The mean CCT (P = 0.001), the total choroidal area (P = 0.001), and the hypo-reflective area (P = 0.003) of the whole choroid were significantly decreased from the baseline at 3 months. The hyperreflective area of whole choroid was not significantly changed during the study period (P = 0.083). The hyperreflective but not the hyporeflective area of the inner choroid was significantly decreased at 3 months (P = 0.001, P = 1.000, respectively). The hyporeflective but not the hyperreflective area of the outer choroid was significantly decreased at 3 months (P = 0.001, P = 1.000, respectively). The hyperreflective area of the inner choroid and hyporeflective area of the outer choroid were significantly decreased after hPDT for chronic CSC. Because the hyperreflective and hyporeflective area correspond to the choroidal stroma and vessels, respectively, the decreased CCT and subfoveal choroidal area after hPDT may be attributed to a decrease in the exudative changes in the inner choroidal stroma and the reduction of the dilation of the outer choroidal vessels.
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影响因子：
13.7
作者：
Branchini LA;Adhi M;Regatieri CV;Nandakumar N;Liu JJ;Laver N;Fujimoto JG;Duker JS
通讯作者：
Duker JS
影响因子：
2
作者：
Iwata A;Mitamura Y;Niki M;Semba K;Egawa M;Katome T;Sonoda S;Sakamoto T
通讯作者：
Sakamoto T
DOI：
10.1097/iae.0b013e3181be0a83
发表时间：
2009-11-01
影响因子：
3.3
作者：
Imamura, Yutaka;Fujiwara, Takamitsu;Spaide, Richard F.
通讯作者：
Spaide, Richard F.
DOI：
10.1097/00006982-199911000-00005
发表时间：
1999-01-01
影响因子：
3.3
作者：
Iida, T;Kishi, S;Shimizu, K
通讯作者：
Shimizu, K
影响因子：
4.2
作者：
Reibaldi, Michele;Cardascia, Nicola;Boscia, Francesco
通讯作者：
Boscia, Francesco