Postmortem examination of patient H.M.'s brain based on histological sectioning and digital 3D reconstruction.
Postmortem examination of patient H.M.'s brain based on histological sectioning and digital 3D reconstruction.
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DOI：
10.1038/ncomms4122
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发表时间：
2014
影响因子：
16.6
通讯作者：
Corkin, Suzanne
中科院分区：
文献类型：
--
作者：
Annese, Jacopo;Schenker-Ahmed, Natalie M.;Bartsch, Hauke;Maechler, Paul;Sheh, Colleen;Thomas, Natasha;Kayano, Junya;Ghatan, Alexander;Bresler, Noah;Frosch, Matthew P.;Klaming, Ruth;Corkin, Suzanne
现代科学知识的记忆功能是如何组织在人类大脑起源于案件的亨利G。Molaison（H.M.），一名癫痫患者，在双侧手术切除内侧颞叶结构（包括海马体）后意外地发生了健忘症。1953年手术的神经解剖范围在H.M.'期间无法确定。的生活。在这里，我们描述了一个程序的结果，旨在重建整个大脑的显微解剖模型，并进行详细的3D测量内侧颞叶区域。这种方法，结合细胞水平的成像染色的组织切片，显示了显着的残留海马组织与独特的细胞结构。我们的研究还揭示了深层白色物质的弥漫性病变和左侧眶额皮质的一个小的局限性病变。这些发现构成了新的证据，可能有助于阐明H.M.'的后果。在大脑整体病理学的背景下， 关于病人H. M。双侧海马切除会导致长期记忆的巩固受损。Annese等人绘制了亨利·莫莱森大脑的数字地图，发现后海马体的很大一部分实际上在组织学上是完整的。
Modern scientific knowledge of how memory functions are organized in the human brain originated from the case of Henry G. Molaison (H.M.), an epileptic patient whose amnesia ensued unexpectedly following a bilateral surgical ablation of medial temporal lobe structures, including the hippocampus. The neuroanatomical extent of the 1953 operation could not be assessed definitively during H.M.’s life. Here we describe the results of a procedure designed to reconstruct a microscopic anatomical model of the whole brain and conduct detailed 3D measurements in the medial temporal lobe region. This approach, combined with cellular-level imaging of stained histological slices, demonstrates a significant amount of residual hippocampal tissue with distinctive cytoarchitecture. Our study also reveals diffuse pathology in the deep white matter and a small, circumscribed lesion in the left orbitofrontal cortex. The findings constitute new evidence that may help elucidate the consequences of H.M.’s operation in the context of the brain’s overall pathology. Studies on Patient H.M. showed that bilateral resection of the hippocampus results in impaired consolidation of long-term memory. Annese et al. create a digital map of Henry Molaison’s brain and find that a significant portion of the posterior hippocampus is actually histologically intact.
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影响因子：
16.2
作者：
Fanselow, Michael S.;Dong, Hong-Wei
通讯作者：
Dong, Hong-Wei
影响因子：
3.5
作者：
O'Kane, G;Kensinger, EA;Corkin, S
通讯作者：
Corkin, S
DOI：
10.1073/pnas.1306244110
发表时间：
2013-05-21
影响因子：
11.1
作者：
Insausti, Ricardo;Annese, Jacopo;Squire, Larry R.
通讯作者：
Squire, Larry R.
影响因子：
2.6
作者：
CORKIN, S
通讯作者：
CORKIN, S
影响因子：
9.9
作者：
GHATAK, NR;SANTOSO, RA;MCKINNEY, WM
通讯作者：
MCKINNEY, WM