A finely resolved phylogeny of Y chromosome Hg J illuminates the processes of Phoenician and Greek colonizations in the Mediterranean.
A finely resolved phylogeny of Y chromosome Hg J illuminates the processes of Phoenician and Greek colonizations in the Mediterranean.
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DOI：
10.1038/s41598-018-25912-9
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发表时间：
2018-05-10
影响因子：
4.6
通讯作者：
Novelletto A
中科院分区：
文献类型：
--
作者：
Finocchio A;Trombetta B;Messina F;D'Atanasio E;Akar N;Loutradis A;Michalodimitrakis EI;Cruciani F;Novelletto A
为了改善地中海北部海岸希腊人和腓尼基人殖民的男性特有遗传痕迹的系统地理，我们对土耳其、希腊和意大利的J单倍群的七个亚支进行了地理结构抽样。我们对58例受试者的Y染色体4.4Mb进行了重测序，获得了1079个高质量的变异体。我们没有发现土耳其样本优先合并到祖先节点，这与汞J作为一个整体从中东扩散和辐射的简单化想法相矛盾。在与古老的汞J染色体进行校准后，我们证实了全新世汞J辐射的迹象是微妙的，主要可以追溯到青铜时代。我们精确地找到了七种可能揭示星团序列的变体，这表明了局部扩张。通过直接对汞J携带者的这些变异进行基因分型，并与已公布的重新测序的染色体(893名受试者)进行补充，我们为希腊大格雷西亚人(jia-l397)和腓尼基人迁徙(Rs760148062)的标记提供了强有力的时间和分布证据。我们的工作产生了一个进化上稳定的标记的最小但强大的清单，以阐明在过去6000年里，地中海及其周围由男性中介的流动的人口动力学和空间域。
In order to improve the phylogeography of the male-specific genetic traces of Greek and Phoenician colonizations on the Northern coasts of the Mediterranean, we performed a geographically structured sampling of seven subclades of haplogroup J in Turkey, Greece and Italy. We resequenced 4.4 Mb of Y-chromosome in 58 subjects, obtaining 1079 high quality variants. We did not find a preferential coalescence of Turkish samples to ancestral nodes, contradicting the simplistic idea of a dispersal and radiation of Hg J as a whole from the Middle East. Upon calibration with an ancient Hg J chromosome, we confirmed that signs of Holocenic Hg J radiations are subtle and date mainly to the Bronze Age. We pinpointed seven variants which could potentially unveil star clusters of sequences, indicative of local expansions. By directly genotyping these variants in Hg J carriers and complementing with published resequenced chromosomes (893 subjects), we provide strong temporal and distributional evidence for markers of the Greek settlement of Magna Graecia (J2a-L397) and Phoenician migrations (rs760148062). Our work generated a minimal but robust list of evolutionarily stable markers to elucidate the demographic dynamics and spatial domains of male-mediated movements across and around the Mediterranean, in the last 6,000 years.
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影响因子：
2.8
作者：
Davison, K;Dolukhanov, P;Shukurov, A
通讯作者：
Shukurov, A
影响因子：
64.8
作者：
Fu Q;Posth C;Hajdinjak M;Petr M;Mallick S;Fernandes D;Furtwängler A;Haak W;Meyer M;Mittnik A;Nickel B;Peltzer A;Rohland N;Slon V;Talamo S;Lazaridis I;Lipson M;Mathieson I;Schiffels S;Skoglund P;Derevianko AP;Drozdov N;Slavinsky V;Tsybankov A;Cremonesi RG;Mallegni F;Gély B;Vacca E;Morales MR;Straus LG;Neugebauer-Maresch C;Teschler-Nicola M;Constantin S;Moldovan OT;Benazzi S;Peresani M;Coppola D;Lari M;Ricci S;Ronchitelli A;Valentin F;Thevenet C;Wehrberger K;Grigorescu D;Rougier H;Crevecoeur I;Flas D;Semal P;Mannino MA;Cupillard C;Bocherens H;Conard NJ;Harvati K;Moiseyev V;Drucker DG;Svoboda J;Richards MP;Caramelli D;Pinhasi R;Kelso J;Patterson N;Krause J;Pääbo S;Reich D
通讯作者：
Reich D
DOI：
10.1073/pnas.1418652112
发表时间：
2015-03-17
影响因子：
11.1
作者：
Harris, Kelley
通讯作者：
Harris, Kelley
影响因子：
10.7
作者：
Cruciani, Fulvio;La Fratta, Roberta;Scozzari, Rosaria
通讯作者：
Scozzari, Rosaria
影响因子：
5.2
作者：
Chiaroni, Jacques;King, Roy J.;Underhill, Peter A.
通讯作者：
Underhill, Peter A.