Age-related changes in envelope-following responses at equalized peripheral or central activation.
Age-related changes in envelope-following responses at equalized peripheral or central activation.
复制标题
DOI：
10.1016/j.neurobiolaging.2017.06.013
复制
发表时间：
2017-10
影响因子：
4.2
通讯作者：
Bartlett EL
中科院分区：
文献类型：
--
作者：
Lai J;Sommer AL;Bartlett EL
先前的工作一直在争论在听觉创伤或年龄相关的变化后，听力阈值和诱发电位的变化在各组之间的听力能力的比较。本研究比较了年轻和年老大鼠的包膜跟随反应（EFRs），根据(1)8 kHz音调引起的听觉脑干反应（ABRs）的波1振幅或(2)在100%深度的正弦振幅调制（SAM）音调引起的EFR振幅匹配声级。不同年龄的匹配波I振幅对应于大约20分贝的声级差异。对于匹配的波I，波V振幅没有观察到与年龄相关的差异。然而，安静状态下记录的EFRs随着老化深度达到100%而增强，而不是25%，这与老化时中心增益增强一致。对于匹配的EFRs， AM深度和AM频率处理的EFRs没有年龄相关的差异。这些结果提出了一种新的、客观的、超越阈值的测量方法，以补偿听神经激活的差异，并区分外周和中枢efr的贡献。
Previous work has debated about comparisons of hearing abilities faced with alterations in hearing thresholds and evoked potentials between groups following acoustic trauma- or age-related changes. This study compares envelope following responses (EFRs) of young and aged rats when sound levels were matched according to (1) wave I amplitudes of auditory brainstem responses (ABRs) elicited by 8 kHz tones or (2) EFR amplitudes evoked by sinusoidally amplitude modulated (SAM) tones at 100 % depth. Matched wave I amplitudes across age corresponded to approximately 20 dB sound level differences. For matched wave I, no age-related differences were observed in wave V amplitudes. However, EFRs recorded in quiet were enhanced with aging at 100 % but not 25 % depth, consistent with enhanced central gain in aging. For matched EFRs, there were no age-related differences in EFRs of AM depth and AM frequency processing. These results suggest novel, objective measures beyond threshold to compensate for differences in auditory nerve activation and to differentiate peripheral and central contributions of EFRs.
登录
查看更多内容
MEG揭示的对听觉频率遵循响应的皮质贡献。
影响因子：
16.6
作者：
Coffey EB;Herholz SC;Chepesiuk AM;Baillet S;Zatorre RJ
通讯作者：
Zatorre RJ
影响因子：
2.8
作者：
Clinard CG;Tremblay KL;Krishnan AR
通讯作者：
Krishnan AR
影响因子：
16.2
作者：
Chambers AR;Resnik J;Yuan Y;Whitton JP;Edge AS;Liberman MC;Polley DB
通讯作者：
Polley DB
影响因子：
1.2
作者：
Bramhall, Naomi;Ong, Bonnie;Parker, Mark
通讯作者：
Parker, Mark
影响因子：
2.9
作者：
Choi, Inyong;Bharadwaj, Hari M.;Shinn-Cunningham, Barbara G.
通讯作者：
Shinn-Cunningham, Barbara G.