Environmental enrichment enhances episodic-like memory in association with a modified neuronal activation profile in adult mice.
Environmental enrichment enhances episodic-like memory in association with a modified neuronal activation profile in adult mice.
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DOI：
10.1371/journal.pone.0048043
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Schumann-Bard P
中科院分区：
文献类型：
--
作者：
Leger M;Quiedeville A;Paizanis E;Natkunarajah S;Freret T;Boulouard M;Schumann-Bard P
虽然环境丰富是众所周知的，以改善学习和记忆的啮齿动物，潜在的神经网络的可塑性仍然很少描述。丰富条件（EC）的大脑激活模式的修改，特别是在额叶皮层和基底外侧杏仁核，已报告在啮齿动物的厌恶记忆任务。本研究的目的是：1）EC是否调节物体识别任务中的情节样记忆; 2）EC是否调节任务诱导的神经元网络。为此，在行为实验之前，将成年雄性小鼠在标准条件（SC）或EC中饲养三周（n = 12/组）。 在Y型迷宫中进行的物体识别任务中检查记忆性能，呈现和测试之间有2小时或24小时的延迟（会话间间隔，ISI）。为了表征EC的促进作用的机制，使用免疫组织化学技术以c-Fos作为神经元激活标记物，在演示或测试会话后评估脑激活概况。EC没有调制后2小时ISI的记忆性能，但延长物体识别记忆到24小时ISI。相比之下，SC小鼠在此ISI下不区分新对象。与SC小鼠相比，在EC小鼠的选定脑区中未发现与呈现期相关的激活（特别是，在海马和嗅周皮质中未发现影响，在基底外侧杏仁核中发现激活减少）。另一方面，在EC小鼠的测试阶段后观察到海马和边缘下皮层的激活，但SC小鼠没有。这些结果表明，EC中物体识别记忆的持久性可能与早在记忆编码时发生的神经网络重组有关。
Although environmental enrichment is well known to improve learning and memory in rodents, the underlying neuronal networks' plasticity remains poorly described. Modifications of the brain activation pattern by enriched condition (EC), especially in the frontal cortex and the baso-lateral amygdala, have been reported during an aversive memory task in rodents. The aims of our study were to examine 1) whether EC modulates episodic-like memory in an object recognition task and 2) whether EC modulates the task-induced neuronal networks. To this end, adult male mice were housed either in standard condition (SC) or in EC for three weeks before behavioral experiments (n = 12/group). Memory performances were examined in an object recognition task performed in a Y-maze with a 2-hour or 24-hour delay between presentation and test (inter-session intervals, ISI). To characterize the mechanisms underlying the promnesiant effect of EC, the brain activation profile was assessed after either the presentation or the test sessions using immunohistochemical techniques with c-Fos as a neuronal activation marker. EC did not modulate memory performances after a 2 h-ISI, but extended object recognition memory to a 24 h-ISI. In contrast, SC mice did not discriminate the novel object at this ISI. Compared to SC mice, no activation related to the presentation session was found in selected brain regions of EC mice (in particular, no effect was found in the hippocampus and the perirhinal cortex and a reduced activation was found in the baso-lateral amygdala). On the other hand, an activation of the hippocampus and the infralimbic cortex was observed after the test session for EC, but not SC mice. These results suggest that the persistence of object recognition memory in EC could be related to a reorganization of neuronal networks occurring as early as the memory encoding.
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影响因子：
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作者：
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通讯作者：
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