Bacteroides gingivalis-specific serum IgG and IgA subclass antibodies in periodontal diseases.
Bacteroides gingivalis-specific serum IgG and IgA subclass antibodies in periodontal diseases.
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牙周病中牙龈拟杆菌特异性血清 IgG 和 IgA 亚类抗体。
DOI：
10.1111/j.1365-2249.1990.tb05446.x
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发表时间：
1990
影响因子：
4.6
通讯作者：
Kiyono,H
中科院分区：
文献类型：
--
作者：
Ogawa,T;Kusumoto,Y;Hamada,S;McGhee,JR;Kiyono,H
血清IgM、IgG和IgA抗体水平包括IgG1。采用ELISA法对不同牙周病（PD）患者和对照组的IgG2、IgG3、IgG4、IgA1和IgA2亚类特异性抗体对牙龈卟啉单胞菌（Porphyromonas）和脂多糖（LPS）进行检测。在PD受试者中，血清取自成人牙周炎（AP）。快速进展性牙周炎（RPP）和牙龈炎含有高升的菌毛特异性IgG抗体（7500-15000 ELISA单位），其次是IgA（90-700单位）和IgM（30-90单位）。相比之下，局部青少年牙周炎（LJP）患者血清中菌毛特异性IgG（89±11个单位）、IgA（31.5个单位）和IgM（17±3个单位）抗体的滴度要低得多。同样的反应模式也出现在35-41岁正常口腔卫生的正常受试者的血清中，而具有良好口腔卫生的年轻人（18-24岁）的血清中没有任何抗原特异性抗体。IgG亚类抗菌膜反应分析显示，AP、RPP和牙龈炎的主要反应是IgG3，其次是IgG1、IgG2和IgG4。虽然较低，但在35-41岁的LJP和正常受试者中发现了相似的IgG亚类滴度模式。当在AP和RPP中测量IgA亚类反应时，与IgA2相比，IgAl注意到更高滴度的纤维特异性反应。然而，在其他PD组中观察到较低但大致相等的毛特异性IgAl和IgA2滴度。当anti-B。结果显示，AP患者血清中IgG抗体含量较高（2265±224单位），IgA抗体含量较高（411±90单位），IgM抗体含量较高（214±56单位）。进一步。IgG抗lps反应主要是IgG2，其次是IgG4。IgG3和IgGI。对于IgA亚类反应，IgA2亚类中抗lps特异性抗体的滴度高于IgAl。结果表明，抗- b。与健康个体相比，PD患者出现牙龈抗体反应，并出现b蛋白和脂碳水化合物抗原。牙龈炎诱导不同模式的抗原特异性IgG和IgA亚类反应。
The level of serum IgM, IgG and IgA antibodies including IgG1. IgG2, IgG3, IgG4, IgA1 and IgA2 subclass-specific antibodies toBacteroides (Porphyromonas) gingivalisfimbriae and to lipopolysaccharide(LPS) were analysed in paiients with different forms of periodontal disease (PD) and control subjects by ELISA. Among PD subjects, sera obtained from adult periodonitis (AP). rapidly progressive periodontitis (RPP) and gingivitis contained high litres of fimbriae-specific IgG antibodies (7500–15000 ELISA units) followed by IgA (90–700 units) and IgM (30–90 units). In contrast, sera from localized juvenile periodontitis (LJP) subjects exhibited much lower titres of fimbriae-specific IgG (89 ± 11 units), IgA (31.5 units) and IgM (17 ± 3 units) antibodies. A similar response pattern was also seen in sera from normal subjects aged 35–41 years who practice normal oral hygiene, while sera of younger adults (aged 18–24) with superior hygiene did not have any antigen-specific antibodies. Analysis of IgG subclass anti-fimbriae responses revealed that the major response was IgG3 followed by IgG1, IgG2 and IgG4 in AP, RPP and gingivitis. Although lower, a similar pattern of IgG subclass titre was seen in LJP and normal subjects aged 35–41 years. When IgA subclass responses were measured in AP and RPP, higher titres of the fimbriae-specific response were noted with IgAl when compared with IgA2. However, lower but approximately equal levels of fimbriae-specific IgAl and IgA2 titres were seen in other PD groups. When anti-B.gingivalisLPS-specific responses were measured, the sera of AP patients contained high levels of IgG antibodies (2265 ± 224 units) followed by IgA (411 ± 90 units) and IgM (214 ± 56 units). Further. IgG anti-LPS responses were mainly IgG2 followed by IgG4. IgG3 and IgGI. For IgA subclass responses, higher titres of anti-LPS-specific antibodies were noted in IgA2 subclass over IgAl. These results showed that higher anti-B. gingivalisantibody responses occur in PD when compared with healthy individuals and protein and lipid-carbohydrate antigens ofB. gingivalisinduce distinct patterns of antigen-specific IgG and IgA subclass responses.
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DOI：
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期刊：
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影响因子：
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DOI：
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期刊：
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影响因子：
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作者：
Ogawa,T;Tarkowski,A;McGhee,ML;Moldoveanu,Z;Mestecky,J;Hirsch,HZ;Koopman,WJ;Hamada,S;McGhee,JR;Kiyono,H
通讯作者：
Kiyono,H