Basic Research on Tendon Repair: Strategies, Evaluation, and Development.
Basic Research on Tendon Repair: Strategies, Evaluation, and Development.
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肌腱修复的基础研究：策略、评估和发展
DOI：
10.3389/fmed.2021.664909
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发表时间：
2021
影响因子：
3.9
通讯作者：
Zhou YL
中科院分区：
文献类型：
--
作者：
Li ZJ;Yang QQ;Zhou YL
肌腱是一种连接肌肉和骨骼的纤维弹性结构。肌腱损伤可分为慢性和急性两种类型。每种类型的损伤或退变都可能导致严重的疼痛和肌腱功能丧失。肌腱损伤的自然愈合过程是复杂的。根据肌腱组织的解剖位置，临床结果有所不同。伤口愈合过程包括三个重叠的阶段：伤口愈合、增殖和组织重塑。此外，愈合的肌腱还面临着较高的再撕裂率。面对上述困难，肌腱损伤的治疗仍然是一个临床问题，亟待解决。近年来，肌腱愈合有许多新的方向和进展。这篇综述介绍了肌腱损伤，并总结了近年来肌腱愈合的发展，包括基因治疗、干细胞治疗、富血小板血浆（PRP）治疗、生长因子和药物治疗以及组织工程。尽管这些治疗方法大多尚未发展到成熟的临床应用阶段，但随着研究人员的反复验证和疗效的不断优化，那一天不会太遥远。
Tendon is a fibro-elastic structure that links muscle and bone. Tendon injury can be divided into two types, chronic and acute. Each type of injury or degeneration can cause substantial pain and the loss of tendon function. The natural healing process of tendon injury is complex. According to the anatomical position of tendon tissue, the clinical results are different. The wound healing process includes three overlapping stages: wound healing, proliferation and tissue remodeling. Besides, the healing tendon also faces a high re-tear rate. Faced with the above difficulties, management of tendon injuries remains a clinical problem and needs to be solved urgently. In recent years, there are many new directions and advances in tendon healing. This review introduces tendon injury and sums up the development of tendon healing in recent years, including gene therapy, stem cell therapy, Platelet-rich plasma (PRP) therapy, growth factor and drug therapy and tissue engineering. Although most of these therapies have not yet developed to mature clinical application stage, with the repeated verification by researchers and continuous optimization of curative effect, that day will not be too far away.
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