Precisely timed theta oscillations are selectively required during the encoding phase of memory.
Precisely timed theta oscillations are selectively required during the encoding phase of memory.
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DOI：
10.1038/s41593-021-00919-0
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发表时间：
2021-11
影响因子：
25
通讯作者：
Leutgeb S
中科院分区：
文献类型：
--
作者：
Quirk CR;Zutshi I;Srikanth S;Fu ML;Devico Marciano N;Wright MK;Parsey DF;Liu S;Siretskiy RE;Huynh TL;Leutgeb JK;Leutgeb S
人们假设大脑振荡通过协调大脑区域内和跨区域的脉冲时间来支持认知功能，但通常不知道时间是神经计算的关键还是一种附带现象。内嗅皮层和海马体是学习和记忆所必需的，并表现出明显的θ振荡（6 - 9hz），这是由内侧间隔区（MSA）的起搏器细胞控制的。本研究表明，小蛋白阳性MSA神经元的节律性光刺激强烈地改变了小鼠内嗅和海马神经元的活动模式。尽管有强烈的卷带，但在空间工作记忆任务中，只有当起搏频率达到或低于内源性θ频率时才会出现记忆损伤，只有当起搏频率≥10 Hz时才会出现记忆损伤，特别是当起搏频率针对编码发生的迷宫片段时。因此，编码阶段的神经计算被神经元放电模式的时间扰动选择性地中断。
Brain oscillations have been hypothesized to support cognitive function by coordinating spike timing within and across brain regions, yet it is often not known when timing is either critical for neural computations or an epiphenomenon. The entorhinal cortex and hippocampus are necessary for learning and memory and exhibit prominent theta oscillations (6–9 Hz), which are controlled by pacemaker cells in the medial septal area (MSA). Here we show that entorhinal and hippocampal neuronal activity patterns were strongly entrained by rhythmic optical stimulation of parvalbumin-positive MSA neurons in mice. Despite strong entrainment, memory impairments in a spatial working memory task were not observed with pacing frequencies at or below the endogenous theta frequency and only emerged at frequencies ≥10 Hz and specifically when pacing was targeted to maze segments where encoding occurs. Neural computations during the encoding phase were therefore selectively disrupted by perturbations of the timing of neuronal firing patterns.
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