The Human Mucosal Mycobiome and Fungal Community Interactions.
The Human Mucosal Mycobiome and Fungal Community Interactions.
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DOI：
10.3390/jof3040056
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发表时间：
2017-10-07
期刊：
影响因子：
--
通讯作者：
Moyes DL
中科院分区：
文献类型：
--
作者：
Witherden EA;Shoaie S;Hall RA;Moyes DL
随着高通量测序技术的出现，我们体内和体表微生物群落的惊人范围和复杂性已经开始变得清晰。此外，随着计算和建模方法的进步，我们现在开始了解我们与这些社区的互动有多么动态。这些群落的多样性及其相互作用（无论是在群落内部还是与我们之间）都取决于多种因素，包括微生物介导的因素和宿主介导的因素。重要的是，越来越清楚的是，这些社区的构成或其反应的变化与不同的疾病状态有关。尽管定义这些相互作用和联系的大部分工作都是在研究细菌群落，但最近知识体系有了显着增长，表明宿主真菌群落（真菌组）的变化也与疾病状态密切相关。在这篇综述中，我们将探讨这些关联，以及真菌群落与其人类和微生物栖息地之间的相互作用，并讨论系统生物学在确定其在疾病状态中的作用方面的未来应用。
With the advent of high-throughput sequencing techniques, the astonishing extent and complexity of the microbial communities that reside within and upon us has begun to become clear. Moreover, with advances in computing and modelling methods, we are now beginning to grasp just how dynamic our interactions with these communities are. The diversity of both these communities and their interactions—both within the community and with us—are dependent on a multitude of factors, both microbial- and host-mediated. Importantly, it is becoming clear that shifts in the makeup of these communities, or their responses, are linked to different disease states. Although much of the work to define these interactions and links has been investigating bacterial communities, recently there has been significant growth in the body of knowledge, indicating that shifts in the host fungal communities (mycobiome) are also intimately linked to disease status. In this review, we will explore these associations, along with the interactions between fungal communities and their human and microbial habitat, and discuss the future applications of systems biology in determining their role in disease status.
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影响因子：
15.9
作者：
Huffnagle, Gary B.;Noverr, Mairi C.
通讯作者：
Noverr, Mairi C.
DOI：
10.1126/science.1221789
发表时间：
2012-06-08
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Iliev ID;Funari VA;Taylor KD;Nguyen Q;Reyes CN;Strom SP;Brown J;Becker CA;Fleshner PR;Dubinsky M;Rotter JI;Wang HL;McGovern DP;Brown GD;Underhill DM
通讯作者：
Underhill DM
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
3.7
作者：
Hoffmann C;Dollive S;Grunberg S;Chen J;Li H;Wu GD;Lewis JD;Bushman FD
通讯作者：
Bushman FD
影响因子：
5.2
作者：
He J;Kim D;Zhou X;Ahn SJ;Burne RA;Richards VP;Koo H
通讯作者：
Koo H