Insect-specific flaviviruses: a systematic review of their discovery, host range, mode of transmission, superinfection exclusion potential and genomic organization.
Insect-specific flaviviruses: a systematic review of their discovery, host range, mode of transmission, superinfection exclusion potential and genomic organization.
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DOI：
10.3390/v7041927
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发表时间：
2015-04-10
期刊：
影响因子：
--
通讯作者：
Firth AE
中科院分区：
文献类型：
--
作者：
Blitvich BJ;Firth AE
在过去的十年中，昆虫特异性黄病毒（ISF）的数量急剧增加。历史上，这些病毒由于不能感染脊椎动物细胞而引起了有限的兴趣。这种观点近年来有所改变，因为一些ISF已被证明可以增强或抑制共感染蚊子细胞中医学上重要的黄病毒的复制。此外，ISF和医学上重要的黄病毒之间的比较研究可以提供一个独特的视角，为什么一些黄病毒具有感染人类并导致毁灭性疾病的能力，而其他人则没有。ISF在自然界中只从蚊子中分离出来，但在白蛉和摇蚊中检测到ISF样序列表明它们也可能感染其他双翅目昆虫。ISF可以分为两个不同的系统发育组。第一组病毒目前由大约12种病毒组成，包括细胞融合剂病毒、卡米蒂河病毒和库蚊黄病毒。这些病毒在遗传学上不同于所有其他已知的黄病毒。第二组病毒显然不是单系的，目前由9种病毒组成，包括朝阳病毒、努纳内病毒和拉米病毒。这些病毒在遗传学上与蚊子/脊椎动物黄病毒相关，尽管它们具有明显的昆虫限制性表型。本文就ISFs的发现、宿主范围、传播方式、排除重复感染能力和基因组结构等方面进行综述。本文还试图澄清ISF命名法，因为这些病毒中的一些已经被分配了一个以上的名称，由于他们同时发现的独立研究小组。
There has been a dramatic increase in the number of insect-specific flaviviruses (ISFs) discovered in the last decade. Historically, these viruses have generated limited interest due to their inability to infect vertebrate cells. This viewpoint has changed in recent years because some ISFs have been shown to enhance or suppress the replication of medically important flaviviruses in co-infected mosquito cells. Additionally, comparative studies between ISFs and medically important flaviviruses can provide a unique perspective as to why some flaviviruses possess the ability to infect and cause devastating disease in humans while others do not. ISFs have been isolated exclusively from mosquitoes in nature but the detection of ISF-like sequences in sandflies and chironomids indicates that they may also infect other dipterans. ISFs can be divided into two distinct phylogenetic groups. The first group currently consists of approximately 12 viruses and includes cell fusing agent virus, Kamiti River virus and Culex flavivirus. These viruses are phylogenetically distinct from all other known flaviviruses. The second group, which is apparently not monophyletic, currently consists of nine viruses and includes Chaoyang virus, Nounané virus and Lammi virus. These viruses phylogenetically affiliate with mosquito/vertebrate flaviviruses despite their apparent insect-restricted phenotype. This article provides a review of the discovery, host range, mode of transmission, superinfection exclusion ability and genomic organization of ISFs. This article also attempts to clarify the ISF nomenclature because some of these viruses have been assigned more than one name due to their simultaneous discoveries by independent research groups.
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影响因子：
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作者：
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